Publication Name	World Journal of Hypertension
Manuscript ID	42832
Country	United States

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Basic Study
Article Title	Loss of cavin1 and expression of p-caveolin-1 in pulmonary hypertension: Possible role in neointima formation
Manuscript Source	Unsolicited Manuscript
All Author List	Jing Huang and Rajamma Mathew
Funding Agency and Grant Number
Corresponding Author	Rajamma Mathew, MD, Associate Professor, Department of and Physiology, New York Medical College, 15 Dana Road, Rm A11, Basic science Building, Valhalla, NY 10595, United States. rajamma_mathew@nymc.edu
Key Words	Caveolin-1; Cavin-1; Neointima; Phospho-caveolin1; Pulmonary hypertension
Core Tip	Neointima leads to irreversible pulmonary hypertension (PH). Subjecting the monocrotaline (MCT)-injected rats to hypoxia accelerates the disease process; by 4 wk, neointima develops in arteries with extensive disruption of endothelial cells (EC), loss of endothelial caveolin-1 (cav-1), and enhanced cav-1 expression in smooth muscle cells. In addition, the MCT and MCT+ hypoxia groups exhibit significant loss of cavin-1 and the presence of tyrosine phosphorylated cav-1, which may facilitate cell migration and neointima formation. Hypoxia-induced PH does not exhibit EC disruption or alterations in cav-1 expression. Thus, EC integrity may determine the reversibility or irreversibility of PH.
Citation	Huang J, Mathew R. Loss of cavin1 and expression of p-caveolin-1 in pulmonary hypertension: Possible role in neointima formation. World J Hypertens 2019; 9(2): 17-29

Received	2018-10-11 10:39
Peer-Review Started	2018-10-12 09:20
To Make the First Decision	2018-12-06 02:48
Return for Revision	2018-12-18 06:02
Revised	2019-01-08 19:18
Second Decision	2019-03-08 08:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-12 15:08
Articles in Press	2019-03-12 15:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-04-24 02:21

ISSN	2220-3168 (online)
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