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Publication Name World Journal of Hypertension
Manuscript ID 42832
Country of Manuscript Source United States
Specialty Cardiac and Cardiovascular Systems
Manuscript type Basic Study
Article Title Loss of cavin1 and expression of p-caveolin-1 in pulmonary hypertension: Possible role in neointima formation
Manuscript Source Unsolicited Manuscript
All Author List Jing Huang and Rajamma Mathew
Funding Agency and Grant Number
Correspondence To Rajamma Mathew, MD, Associate Professor, Associate Professor, Pediatrics and Physiology, Department of and Physiology, New York Medical College, 15 Dana Road, Rm A11, Basic science Building, Valhalla, NY10595, United States. rajamma_mathew@nymc.edu
Keywords Caveolin-1; Cavin-1; Neointima; Phospho-caveolin1; Pulmonary hypertension
Core Tip Neointima leads to irreversible pulmonary hypertension (PH). Subjecting the monocrotaline (MCT)-injected rats to hypoxia accelerates the disease process; by 4 wk, neointima develops in arteries with extensive disruption of endothelial cells (EC), loss of endothelial caveolin-1 (cav-1), and enhanced cav-1 expression in smooth muscle cells. In addition, the MCT and MCT+ hypoxia groups exhibit significant loss of cavin-1 and the presence of tyrosine phosphorylated cav-1, which may facilitate cell migration and neointima formation. Hypoxia-induced PH does not exhibit EC disruption or alterations in cav-1 expression. Thus, EC integrity may determine the reversibility or irreversibility of PH.
Citation Huang J, Mathew R. Loss of cavin1 and expression of p-caveolin-1 in pulmonary hypertension: Possible role in neointima formation. World J Hypertens 2019; 9(2): 17-29
Received
2018-10-11 10:39
Peer-Review Started
2018-10-12 09:20
To Make the First Decision
2018-12-06 02:48
Return for Revision
2018-12-18 06:02
Revised
2019-01-08 19:18
Second Decision
2019-03-08 08:12
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 15:08
Articles in Press
2019-03-12 15:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-24 02:21
ISSN 2220-3168 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 02565578, 03702209, and 03639986
Editorial Director Ya-Juan Ma
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor Yan-Liang Zhang
Responsible Electronic Editor Yan-Liang Zhang
Responsible Science Editor Ya-Juan Ma
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJH-9-17.pdf
Full Article (Word) WJH-9-17.docx
Manuscript File 42832-Review.doc
Answering Reviewers 42832-Answering reviewers.pdf
Audio Core Tip 42832-Audio core tip.mp3
Biostatistics Review Certificate 42832-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42832-Conflict-of-interest statement.pdf
Copyright License Agreement 42832-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 42332-Institutional animal care and use committee statement.pdf
Peer-review Report 42832-Peer-review(s).pdf
Scientific Misconduct Check 42832-Scientific misconduct check.pdf
Scientific Editor Work List 42832-Scientific editor work list.pdf