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Publication Name World Journal of Gastroenterology
Manuscript ID 42856
Country of Manuscript Source Spain
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort
Manuscript Source Invited Manuscript
All Author List Patricia Prieto, Rafael I Jaén, Daniel Calle, María Gómez-Serrano, Estefanía Núñez, María Fernández-Velasco, Paloma Martín-Sanz, Sergio Alonso, Jesús Vázquez, Sebastián Cerdán, Miguel Ángel Peinado and Lisardo Boscá
Funding Agency and Grant Number
Funding Agency Grant Number
MINECO SAF2017-82436R, SAF2016-75004R
MINECO RTC-2017-6283-1, BIO2015-67580P
Comunidad de Madrid S2017/BMD-3686
Fundación Ramón Areces 2016/CIVP18A3864
Instituto de Salud Carlos III, Spain, CIBERCV CB/11/00222 and CB16/11/00277
Fondos FEDER CIBEREHD
Ministerio de Ciencia, Innovación y Universidades (MCNU)
Pro CNIC Foundation
Severo Ochoa Center of Excellence SEV-2015-0505
Correspondence To Lisardo Boscá, PhD, Professor, Senior Scientist, Department of Metabolism and Physiopathology of Inflammatory Diseases, Instituto de investigaciones Biomédicas “Alberto Sols”, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es
Keywords Colon; Carcinoma; Cyclooxygenase; Prostaglandin; Proteomics; High resolution magic angle spinning
Core Tip Although increased levels of cyclooxygenase-2 (COX-2) have been broadly related to colorectal cancer (CRC), high variability exists among patients. In our cohort, the electrophoretic band profile of COX-2 was altered in tumor tissue due to COX-2 glycosylation. Furthermore, prostaglandin E2 levels in tumor tissue were significantly lower than in normal colonic mucosa. In order to further characterize these samples, we have also detected an altered metabolic and proteomic profile in the tumor samples compared to controls that can be associated with the presence of glycosylated COX-2. These findings contribute to delineate the post-translational complexity and heterogeneity of molecular signaling regulation in CRC progression.
Citation Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L. Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort. World J Gastroenterol 2019; 25(4): 433-446
Received
2018-10-17 01:27
Peer-Review Started
2018-10-17 07:56
To Make the First Decision
2018-12-05 06:15
Return for Revision
2018-12-05 09:03
Revised
2018-12-21 09:21
Second Decision
2019-01-10 02:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-10 05:59
Articles in Press
2019-01-10 05:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-25 02:17
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 00572720, 03459541, and 03001969
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Shu-Yu Yin
Responsible Electronic Editor Shu-Yu Yin
Responsible Science Editor Ze-Mao Gong
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-25-433.pdf
Full Article (Word) WJG-25-433.docx
Manuscript File 42856-Review.docx
Answering Reviewers 42856-Answering reviewers.pdf
Audio Core Tip 42856-Audio core tip.mp3
Biostatistics Review Certificate 42856-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 42856-Conflict-of-interest statement.pdf
Copyright License Agreement 42856-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 42856-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 42856-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 42856-Language certificate.pdf
Supplementary Material 42856-Supplementary material.pdf
Peer-review Report 42856-Peer-review(s).pdf
Scientific Misconduct Check 42856-Scientific misconduct check.pdf
Scientific Editor Work List 42856-Scientific editor work list.pdf