Publication Name	World Journal of Gastroenterology
Manuscript ID	42856
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort
Manuscript Source	Invited Manuscript
All Author List	Patricia Prieto, Rafael I Jaén, Daniel Calle, María Gómez-Serrano, Estefanía Núñez, María Fernández-Velasco, Paloma Martín-Sanz, Sergio Alonso, Jesús Vázquez, Sebastián Cerdán, Miguel Ángel Peinado and Lisardo Boscá
Funding Agency and Grant Number	Funding Agency Grant Number MINECO SAF2017-82436R, SAF2016-75004R MINECO RTC-2017-6283-1, BIO2015-67580P Comunidad de Madrid S2017/BMD-3686 Fundación Ramón Areces 2016/CIVP18A3864 Instituto de Salud Carlos III, Spain, CIBERCV CB/11/00222 and CB16/11/00277 Fondos FEDER CIBEREHD Ministerio de Ciencia, Innovación y Universidades (MCNU) Pro CNIC Foundation Severo Ochoa Center of Excellence SEV-2015-0505
Corresponding Author	Lisardo Boscá, PhD, Professor, Department of Metabolism and Physiopathology of Inflammatory Diseases, Instituto de investigaciones Biomédicas “Alberto Sols”, Arturo Duperier 4, Madrid 28029, Spain. lbosca@iib.uam.es
Key Words	Colon; Carcinoma; Cyclooxygenase; Prostaglandin; Proteomics; High resolution magic angle spinning
Core Tip	Although increased levels of cyclooxygenase-2 (COX-2) have been broadly related to colorectal cancer (CRC), high variability exists among patients. In our cohort, the electrophoretic band profile of COX-2 was altered in tumor tissue due to COX-2 glycosylation. Furthermore, prostaglandin E2 levels in tumor tissue were significantly lower than in normal colonic mucosa. In order to further characterize these samples, we have also detected an altered metabolic and proteomic profile in the tumor samples compared to controls that can be associated with the presence of glycosylated COX-2. These findings contribute to delineate the post-translational complexity and heterogeneity of molecular signaling regulation in CRC progression.
Citation	Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L. Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort. World J Gastroenterol 2019; 25(4): 433-446

Received	2018-10-17 01:27
Peer-Review Started	2018-10-17 07:56
To Make the First Decision	2018-12-05 06:15
Return for Revision	2018-12-05 09:03
Revised	2018-12-21 09:21
Second Decision	2019-01-10 02:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-10 05:59
Articles in Press	2019-01-10 05:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-25 02:17

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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