Publication Name	World Journal of Gastroenterology
Manuscript ID	42941
Country	Lithuania

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Ausra Lukosiute-Urboniene, Aldona Jasukaitiene, Giedre Silkuniene, Vidmantas Barauskas, Antanas Gulbinas and Zilvinas Dambrauskas
Funding Agency and Grant Number
Corresponding Author	Ausra Lukosiute-Urboniene, MD, Doctor, Surgeon, Institute for Digestive System Research, Lithuanian University of Health Sciences, Eiveniu Street 4, Kaunas 50161, Lithuania. ausra.urboniene2@lsmuni.lt
Key Words	Pancreatic cancer; Inhibitors of apoptosis proteins; Human antigen R; Post-transcriptional regulation
Core Tip	We report fundamental knowledge about the direct interaction of RNA stabilizing protein human antigen R (HuR) and inhibitor of apoptosis proteins (IAP1, IAP2). Results suggest that upregulation of IAP1 in pancreatic cancer is significantly related to poor outcomes. Furthermore, HuR plays important role in post-transcriptional regulation of these molecules: HuR protein binds with IAP1, IAP2 and after HuR silencing, IAP1 protein and mRNA expression is downregulated and IAP2 is upregulated. These results demonstrate, that HuR regulates expression of IAP1 and IAP2 in pancreatic cancer cells and that IAP1 may be an important factor facilitating carcinogenic properties of HuR.
Citation	Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z. Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer. World J Gastroenterol 2019; 25(2): 205-219

Received	2018-10-18 04:17
Peer-Review Started	2018-10-18 08:16
To Make the First Decision	2018-11-01 06:57
Return for Revision	2018-11-01 09:25
Revised	2018-11-06 17:02
Second Decision	2018-11-16 07:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2018-11-16 18:38
Articles in Press	2018-11-16 18:38
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-14 00:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non- commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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