Publication Name	World Journal of Gastroenterology
Manuscript ID	43228
Country	Italy

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Marco Biolato, Fiorella Manca, Giuseppe Marrone, Consuelo Cefalo, Simona Racco, Giacinto A.D. Miggiano, Venanzio Valenza, Antonio Gasbarrini, Luca Miele and Antonio Grieco
Funding Agency and Grant Number	Funding Agency Grant Number This work was supported by a grant by the Italian Ministry of Education, University and Research (MIUR), scientific research programmes of relevant national interest (PRIN) year 2010-2011 2010C4JJWB
Corresponding Author	Marco Biolato, MD, PhD, Staff Physician, Liver Transplant Medicine, Fondazione Policlinico Universitario A. Gemelli IRCCS, Largo A. Gemelli 8, Rome 00168, Italy. marco.biolato@policlinicogemelli.it
Key Words	Liver steatosis; Gut-liver axis; Nutrition; Personalized medicine; Visceral obesity
Core Tip	Diet, as well as intestinal microbiota, is a key regulator of intestinal permeability, the alteration of which is central in the derangement of the gut-liver axis. In patients with non-alcoholic fatty liver disease (NAFLD), intestinal permeability is increased, promoting translocation of bacteria-derived products into the portal circulation and increasing hepatic exposure to injurious substances that stimulate hepatic inflammation and fibrosis in animal models, high-fat diet or high-fructose intake has been associated with increased gut permeability. The aim of this study was to detect diet-induced modification of intestinal permeability in non-diabetic patients with NAFLD undergoing a Mediterranean diet or a low-fat diet.
Citation	Biolato M, Manca F, Marrone G, Cefalo C, Racco S, Miggiano GA, Valenza V, Gasbarrini A, Miele L, Grieco A. Intestinal permeability after Mediterranean diet and low-fat diet in non-alcoholic fatty liver disease. World J Gastroenterol 2019; 25(4): 509-520

Received	2018-11-05 03:01
Peer-Review Started	2018-11-05 09:26
To Make the First Decision	2018-12-20 06:47
Return for Revision	2018-12-20 08:59
Revised	2019-01-14 17:08
Second Decision	2019-01-18 11:25
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-18 23:05
Articles in Press	2019-01-18 23:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-25 02:24

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com