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Publication Name World Journal of Hepatology
Manuscript ID 43256
Country of Manuscript Source Brazil
Specialty Medicine, Research and Experimental
Manuscript type Basic Study
Article Title Protective action of glutamine in rats with severe acute liver failure
Manuscript Source Unsolicited Manuscript
All Author List Elizângela G Schemitt, Renata M Hartmann, Josieli R Colares, Francielli Licks, Jéferson O Salvi, Cláudio A Marroni and Norma Possa Marroni
Funding Agency and Grant Number
Correspondence To Cláudio A Marroni, MD, PhD, Doctor, Laboratory of Experimental Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Rua José Kanan Aranha 102, Porto Alegre 91760470, Brazil. nmarroni@terra.com.br
Keywords Thioacetamide; Cytokines; Oxidative stress; Inflammation; Liver failure; Chemical and drug induced liver injury; Glutamine
Core Tip Severe acute liver failure (SALF) is a rare syndrome characterized by rapid deterioration of liver function, usually in patients without underlying liver disease; the only effective treatment is transplantation. In this study, we used thioacetamide (TAA), a known xenobiotic hepatotoxicant, to induce SALF in rats. This was followed by administration of glutamine in an attempt to activate antioxidative defenses via the erythroid 2-related factor 2 (Nrf2) pathway and mitigate liver injury. Glutamine successfully activated Nrf2 and inhibited TLR4/NFB-mediated inflammation, allowing restoration of parenchymal architecture and recovery of several parameters to near-control levels.
Citation Schemitt EG, Hartmann RM, Colares JR, Licks F, Salvi JO, Marroni CA, Marroni NP. Protective action of glutamine in rats with severe acute liver failure. World J Hepatol 2019; 11(3): 273-286
Received
2018-10-30 01:13
Peer-Review Started
2018-10-30 08:17
To Make the First Decision
2018-12-11 00:55
Return for Revision
2018-12-21 02:58
Revised
2019-02-22 03:07
Second Decision
2019-03-08 08:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 15:28
Articles in Press
2019-03-12 15:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-27 05:37
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 02527808, 00731613, and 03647881
Editorial Director Fang-Fang Ji
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor Yan-Liang Zhang
Responsible Electronic Editor Yan-Liang Zhang
Responsible Science Editor Ya-Juan Ma
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJH-11-273.pdf
Full Article (Word) WJH-11-273.docx
Manuscript File 43256-Review.docx
Answering Reviewers 43256-Answering reviewers.pdf
Audio Core Tip 43256-Audio core tip.mp3
Biostatistics Review Certificate 43256-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 43256-Conflict-of-interest statement.pdf
Copyright License Agreement 43256-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 43256-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 43256-Institutional review board statement.PDF
Non-Native Speakers of English Editing Certificate 43256-Language certificate.pdf
Peer-review Report 43256-Peer-review(s).pdf
Scientific Misconduct Check 43256-Scientific misconduct check.pdf
Scientific Editor Work List 43256-Scientific editor work list.pdf