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3/12/2019 3:28:12 PM | Browse: 329 | Download: 357
Publication Name World Journal of Hepatology
Manuscript ID 43256
Country/Territory Brazil
Category Medicine, Research & Experimental
Manuscript Type Basic Study
Article Title Protective action of glutamine in rats with severe acute liver failure
Manuscript Source Unsolicited Manuscript
All Author List Elizângela G Schemitt, Renata M Hartmann, Josieli R Colares, Francielli Licks, Jéferson O Salvi, Cláudio A Marroni and Norma Possa Marroni
Funding Agency and Grant Number
Corresponding Author Cláudio A Marroni, MD, PhD, Doctor, Laboratory of Experimental Hepatology and Gastroenterology, Hospital de Clínicas de Porto Alegre, Rua José Kanan Aranha 102, Porto Alegre 91760470, Brazil. nmarroni@terra.com.br
Key Words Thioacetamide; Cytokines; Oxidative stress; Inflammation; Liver failure; Chemical and drug induced liver injury; Glutamine
Core Tip Severe acute liver failure (SALF) is a rare syndrome characterized by rapid deterioration of liver function, usually in patients without underlying liver disease; the only effective treatment is transplantation. In this study, we used thioacetamide (TAA), a known xenobiotic hepatotoxicant, to induce SALF in rats. This was followed by administration of glutamine in an attempt to activate antioxidative defenses via the erythroid 2-related factor 2 (Nrf2) pathway and mitigate liver injury. Glutamine successfully activated Nrf2 and inhibited TLR4/NFB-mediated inflammation, allowing restoration of parenchymal architecture and recovery of several parameters to near-control levels.
Citation Schemitt EG, Hartmann RM, Colares JR, Licks F, Salvi JO, Marroni CA, Marroni NP. Protective action of glutamine in rats with severe acute liver failure. World J Hepatol 2019; 11(3): 273-286
Received
2018-10-30 01:13
Peer-Review Started
2018-10-30 08:17
To Make the First Decision
2018-12-11 00:55
Return for Revision
2018-12-21 02:58
Revised
2019-02-22 03:07
Second Decision
2019-03-08 08:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 15:28
Articles in Press
2019-03-12 15:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-27 05:37
ISSN 1948-5182 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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