Publication Name	World Journal of Gastroenterology
Manuscript ID	43267
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury
Manuscript Source	Unsolicited Manuscript
All Author List	An-Long Ji, Tong Li, Guo Zu, Dong-Cheng Feng, Yang Li, Guang-Zhi Wang, Ji-Hong Yao and Xiao-Feng Tian
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81679154
Corresponding Author	Xiao-Feng Tian, MD, PhD, Director, Professor, Surgeon, Department of General Surgery, The Second Affiliated Hospital of Dalian Medical University, 467 Zhongshan Road, Shahekou District, Dalian 116023, Liaoning Province, China. txfdl@dmu.edu.cn
Key Words	Ubiquitin-specific protease 22; Proliferation; Regeneration; Repair; Intestinal ischemia-reperfusion
Core Tip	The ubiquitin-specific protease 22 (USP22) belongs to the USPs family, which regulate cell cycle progression, proliferation, and tumor invasion. The depleted expression of USP22 has been linked to arrested cell cycle and disrupted distribution and generation of differentiated cell types in crypts and villi. However, its regulatory mechanism remains unclear. By generating models of ischemia reperfusion (I/R) injury and regulating USP22 expression levels, this study reveals USP22 is correlated with promoting intestinal cell proliferation and accelerating intestinal tissue regeneration after intestinal I/R injury. USP22 might serve as a potential target for therapeutic development for tissue repair during intestinal I/R injury.
Citation	Ji AL, Li T, Zu G, Feng DC, Li Y, Wang GZ, Yao JH, Tian XF. Ubiquitin-specific protease 22 enhances intestinal cell proliferation and tissue regeneration after intestinal ischemia reperfusion injury. World J Gastroenterol 2019; 25(7): 824-836

Received	2018-11-06 06:34
Peer-Review Started	2018-11-12 01:16
To Make the First Decision	2018-11-29 09:24
Return for Revision	2018-12-17 07:08
Revised	2019-01-10 02:28
Second Decision	2019-01-18 11:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-18 23:07
Articles in Press	2019-01-18 23:07
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-01-23 01:34
Typeset the Manuscript	2019-02-20 10:24

ISSN	1007-9327 (print) and 2219-2840 (online)
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