Publication Name	World Journal of Gastroenterology
Manuscript ID	43438
Country	Canada

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn’s disease patients
Manuscript Source	Unsolicited Manuscript
All Author List	Alice Jane Foster, Matthew Smyth, Alam Lakhani, Benjamin Jung, Brand F Rollin and Kevan Jacobson
Funding Agency and Grant Number	Funding Agency Grant Number Lutsky Foundation AbbVie Canada
Corresponding Author	Kevan Jacobson, FRCP (C), MD, Doctor, Professor, Senior Scientist, Division of Gastroenterology, Hepatology and Nutrition, British Columbia Children's Hospital, 4480 Oak Street, Room K4-181, Vancouver V6H 3V4, BC, Canada. kjacobson@cw.bc.ca
Key Words	Fecal calprotectin; Disease relapse; Biomarker; Crohn’s disease; Children
Core Tip	It has becoming increasingly evident that many children with Crohn’s disease who are in clinical remission continue to have ongoing active intestinal inflammation. This prospective paediatric study demonstrates the utility of fecal calprotectin monitoring in asymptomatic children with Crohn’s Disease. In this study, a significant number of children were found to have elevated levels despite clinical remission, and levels of > 250 μg/g were found to be a good predictor of clinical relapse in the subsequent 3 mo.
Citation	Foster AJ, Smyth M, Lakhani A, Jung B, Brant RF, Consecutive fecal calprotectin measurements for predicting relapse in pediatric Crohn’s disease patients. World J Gastroenterol 2019; 25(10): 1266-1277

Received	2018-12-05 06:21
Peer-Review Started	2018-12-06 09:55
To Make the First Decision	2019-01-07 02:57
Return for Revision	2019-01-08 01:45
Revised	2019-01-16 06:10
Second Decision	2019-01-18 11:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-18 23:09
Articles in Press	2019-01-18 23:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-13 00:42

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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