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1/30/2019 6:27:07 PM | Browse: 173 | Download: 11
Publication Name World Journal of Gastroenterology
Manuscript ID 44583
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Ursodeoxycholic acid ameliorates lipid metabolism by regulating the AKT/mTOR/SREBP-1 signalling pathway
Manuscript Source Unsolicited Manuscript
All Author List Jie Hu, Wei Hong, Kan-Nan Yao, Xiao-Hong Zhu, Zhi-Yun Chen and Lei Ye
Funding Agency and Grant Number
Funding Agency Grant Number
Natural Science Foundation of Zhejiang province China LQ19H290001
Correspondence To Lei Ye, MAMS, Doctor, Department of Infectious Disease, The First Affiliated Hospital of Zhejiang Chinese Medical University, No. 54 YouDian Road, HangZhou 310006, Zhejiang Province, China. huj520@163.com
Keywords Ursodeoxycholic acid; Hepatic lipid metabolism; AKT/mTOR/SREBP-1; Hepatic steatosis
Core Tip Nonalcoholic fatty liver disease (NAFLD) is the most common form of liver disease. Many studies show that the disorder of hepatic lipid metabolism is major pathogenesis. Increased evidence indicates AKT/mTOR/SREBP-1 signaling pathway is a key pathway to regulate hepatocellular lipid metabolism. At present, there are few studies on the mechanism of NAFLD in hepatic lipid metabolism. We aimed to investigate the functional mechanism of ursodeoxycholic acid (UDCA) in oleic acid induced cellular models of NAFLD. The possible molecular mechanism and related targets of regulating hepatic lipid metabolism were explored, and the correlation between the occurrence of NAFLD and AKT/mTOR/SREBP-1 signaling pathway was explored. We provided more sufficient experimental basis for clinical application of UDCA in the treatment of NAFLD.
Citation Hu J, Hong W, Yao KN, Zhu XH, Chen ZY, Ye L. Ursodeoxycholic acid ameliorates hepatic lipid metabolism in LO2 cells by regulating the AKT/mTOR/SREBP-1 signaling pathway. World J Gastroenterol 2019; In press
Received
2018-11-27 01:14
Peer-Review Started
2018-11-27 03:14
To Make the First Decision
2019-01-11 06:30
Return for Revision
2019-01-11 07:44
Revised
2019-01-29 07:33
Second Decision
2019-01-30 08:41
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-30 18:27
Articles in Press
2019-01-30 18:27
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-02-06 03:10
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7901 Stoneridge Drive, Suite 501, Pleasanton, CA 94588, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 02541409, 02541260, and 02444949
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Peer-review Report 44583-Peer-review(s).pdf
Scientific Misconduct Check 44583-Scientific misconduct check.pdf
Scientific Editor Work List 44583-Scientific editor work list.pdf