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Publication Name World Journal of Clinical Oncology
Manuscript ID 44742
Country of Manuscript Source Germany
Specialty Cell Biology
Manuscript type Basic Study
Article Title Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas
Manuscript Source Invited Manuscript
All Author List Eva Wimmer, Stephan Ihrler, Olivier Gires, Sylvia Streit, Wolfgang Issing and Christoph Bergmann
Funding Agency and Grant Number
Correspondence To Christoph Bergmann, MD, PhD, Assistant Professor, Senior Lecturer, Surgeon, Department of Otorhinolaryngology, University of Duisburg-Essen, Hufelandstr. 55, Essen 45147, Germany. christoph.bergmann@uk-essen.de
Keywords Fibroblast growth factor receptor 4; Single-nucleotide polymorphism; Head and neck squamous cell carcinoma; Reduced survival; Cancer progression; Polymerase chain reaction; Immunohistochemistry; Outcome
Core Tip Single-nucleotide polymorphism Arg388 of the fibroblast growth factor receptor-4 (FGFR4) is associated with a reduced overall survival in patients with various cancers. Here, the potential clinical significance of FGFR4 Arg388 was investigated in the context of head and neck carcinoma in 284 patients using immunohistochemistry and polymerase chain reaction. Advanced tumor stage and local metastasis was significantly associated with reduced disease-free survival in mutant FGFR4 Arg388 carriers. Increased expression of FGFR4 correlated significantly with worse overall survival impacting tumor progression in patients with head and neck squamous cell carcinoma and may present a useful target within a multimodal therapeutic interven-tion.
Citation Wimmer E, Ihrler S, Gieres O, Streit S, Issing W, Bergmann C. Fibroblast growth factor receptor 4 single nucleotide polymorphism Gly388Arg in head and neck carcinomas. World J Clin Oncol 2019; 10(3): 136-148
Received
2018-12-06 00:19
Peer-Review Started
2018-12-06 09:28
To Make the First Decision
2019-01-02 01:06
Return for Revision
2019-01-10 11:00
Revised
2019-01-16 22:20
Second Decision
2019-01-30 08:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-30 19:33
Articles in Press
2019-01-30 19:33
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-22 06:53
ISSN 2218-4333 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 00468686, 03478772, and 03259512
Editorial Director Fang-Fang Ji
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Yun-Xiaojian Wu
Responsible Electronic Editor Yun-Xiaojian Wu
Responsible Science Editor Jin-Lei Wang
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJCO-10-136.pdf
Full Article (Word) WJCO-10-136.docx
Manuscript File 44742-Review.docx
Answering Reviewers 44742-Answering reviewers.pdf
Audio Core Tip 44742-Audio core tip.mp3
Biostatistics Review Certificate 44742-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 44742-Conflict-of-interest statement.pdf
Copyright License Agreement 44742-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 44742--Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 44742-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 44742-Language certificate.pdf
Peer-review Report 44742-Peer-review(s).pdf
Scientific Misconduct Check 44742-Scientific misconduct check.pdf
Scientific Editor Work List 44742-Scientific editor work list.pdf