Publication Name	World Journal of Gastroenterology
Manuscript ID	44765
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients
Manuscript Source	Unsolicited Manuscript
All Author List	Xian-Xian Yuan, Hui-Juan Zhu, Hui Pan, Shi Chen, Ze-Yu Liu, Yue Li, Lin-Jie Wang, Lin Lu, Hong-Bo Yang and Feng-Ying Gong
Funding Agency and Grant Number	Funding Agency Grant Number the National Key Program of Clinical Science No. WBYZ 2011-873 the Chinese Academy of Medical Sciences Innovation Fund for Medical Science No. 2016YFC0901500 the Special Research Fund for Central Universities, Peking Union Medical College No. 2017PT31004
Corresponding Author	Hui-Juan Zhu, MD, Professor, Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission of the People's Republic of China, The Translational Medicine Center of Peking Union Medical College Hospital, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, No. 1 Shuaifuyuan, Dongcheng District, Beijing 100730, China. shengxin2004@163.com
Key Words	Hypopituitarism; Nonalcoholic fatty liver disease; Cirrhosis; Diabetes insipidus; Plasma osmolality
Core Tip	Fifty-four percent of hypopituitary patients in this retrospective study were diagnosed with non-alcoholic fatty liver disease (NAFLD), which was significantly higher than that of the general adult population in China. Growth hormone (GH) deficiency has been considered an important contributing factor to NAFLD in those patients. However, no significant differences were noted in GH and insulin-like growth factor 1 among patients with cirrhosis, subjects with NAFLD and those without NAFLD in this study. Interestingly, we found that the plasma osmolality and serum sodium concentration of the cirrhotic patients were significantly higher than those of the NAFLD patients. In addition, fasting insulin concentration was positively associated with plasma osmolality in patients with NAFLD. Additional studies are required to confirm that hyperosmolality may be a significant contributor to the worsening of NAFLD in hypopituitary patients.
Citation	Yuan XX, Zhu HJ, Pan H, Chen S, Liu ZY, Li Y, Wang LJ, Lu L, Yang HB, Gong FY. Clinical characteristics of non-alcoholic fatty liver disease in Chinese adult hypopituitary patients. World J Gastroenterol 2019; 25(14): 1741-1752

Received	2019-01-13 05:31
Peer-Review Started	2019-01-14 07:10
To Make the First Decision	2019-02-14 02:13
Return for Revision	2019-02-14 05:22
Revised	2019-03-13 02:15
Second Decision	2019-03-15 09:38
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-16 17:58
Articles in Press	2019-03-16 17:58
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-03-25 05:34
Typeset the Manuscript	2019-04-04 01:54

ISSN	1007-9327 (print) and 2219-2840 (online)
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