Publication Name	World Journal of Clinical Cases
Manuscript ID	44870
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Hepatocellular carcinoma patient was successfully treated with ALPPS and apatinib: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ling Liu, Nian-Feng Li, Qi Zhang and Ling Lin
Funding Agency and Grant Number
Corresponding Author	Nian-Feng Li, MD, Doctor, Department of Hepatobiliary and Pancreatic Surgery, Xiangya Hospital, Central south university, Xiangya Hospital, Central South University, Changsha 410008, Hunan Province, China. dlnf66@163.com
Key Words	Hepatocellular carcinoma; Associating liver partition and portal vein ligation for staged hepatectomy; Apatinib; Case report; ;
Core Tip	Our aim was to explore the feasibility of associating liver partition and portal vein ligation for staged hepatectomy (ALPPS) combined with targeted therapy in the treatment of advanced hepatocellular carcinoma (HCC). Herein, we present a case of a 47-year-old male patient with a huge right hepatic mass and an estimated insufficient residual liver, who was successfully treated with ALPPS surgery and apatinib. Postoperative pathology revealed HCC with a significant microvascular embolism. Twenty months later, no tumor reoccurrence was observed, indicating that the combined targeted drug therapy with ALPPS can lead to long-term survival for patients with large HCC.
Citation	Liu L, Li NF, Zhang Q, Lin L. Hepatocellular carcinoma patient was successfully treated with ALPPS and apatinib: A case report. World J Clin Cases 2019; 7(16): 2384-2392

Received	2018-12-03 06:50
Peer-Review Started	2018-12-03 08:38
To Make the First Decision	2019-02-18 03:03
Return for Revision	2019-02-20 00:29
Revised	2019-03-12 20:57
Second Decision	2019-03-15 08:43
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-16 22:57
Articles in Press	2019-03-16 22:57
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-03-21 11:27
Typeset the Manuscript	2019-08-12 00:57

ISSN	2307-8960 (online)
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