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Publication Name World Journal of Gastroenterology
Manuscript ID 44891
Country of Manuscript Source United Kingdom
Specialty Gastroenterology and Hepatology
Manuscript type Review
Article Title Iron and liver fibrosis: Mechanistic and clinical aspects
Manuscript Source Unsolicited Manuscript
All Author List Kosha J Mehta, Sebastien Je Farnaud and Paul A Sharp
Funding Agency and Grant Number
Correspondence To Kosha J Mehta, PhD, Senior Lecturer, Division of Human Sciences, School of Applied Sciences, London South Bank University, 103 Borough Rd, London SE1 0AA, United Kingdom. kosha.mehta@lsbu.ac.uk
Keywords Iron; Liver pathologies; Liver fibrosis; Hepatic stellate cells; Cirrhosis
Core Tip Excess iron is observed in several liver pathologies, where it can accelerate the progression of liver fibrosis to cirrhosis and hepatocellular carcinoma, regardless of disease aetiology. This review narrates the role of excess iron in liver fibrosis. It examines the mechanisms by which iron enhances fibrogenic responses and describes various iron-related clinical pathologies. Furthermore, it evaluates the significance of iron and iron-related proteins in the diagnosis and therapeutics of liver fibrosis. The review is unique in that it includes both, cellular mechanisms and clinical aspects of liver fibrosis pertaining to iron. This makes it distinct from previous published reviews.
Citation Mehta KJ, Farnaud SJ, Sharp PA. Iron and liver fibrosis: Mechanistic and clinical aspects. World J Gastroenterol 2019; 25(5): 521-538
Received
2018-12-02 06:18
Peer-Review Started
2018-12-03 07:14
To Make the First Decision
2018-12-29 01:06
Return for Revision
2018-12-29 02:35
Revised
2019-01-02 08:27
Second Decision
2019-01-04 09:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-01-10 05:51
Articles in Press
2019-01-10 05:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-01-29 06:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 02439220, and 03648851
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Yan Huang
Responsible Electronic Editor Yan Huang
Responsible Science Editor Ze-Mao Gong
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-25-521.pdf
Full Article (Word) WJG-25-521.docx
Manuscript File 44891-Review.docx
Answering Reviewers 44891-Answering reviewers.pdf
Audio Core Tip 44891-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 44891-Conflict-of-interest statement.pdf
Copyright License Agreement 44891-Copyright license agreement.pdf
Peer-review Report 44891-Peer-review(s).pdf
Scientific Misconduct Check 44891-Scientific misconduct check.pdf
Scientific Editor Work List 44891-Scientific editor work list.pdf