Publication Name	World Journal of Gastroenterology
Manuscript ID	44891
Country	United Kingdom

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Iron and liver fibrosis: Mechanistic and clinical aspects
Manuscript Source	Unsolicited Manuscript
All Author List	Kosha J Mehta, Sebastien Je Farnaud and Paul A Sharp
Funding Agency and Grant Number
Corresponding Author	Kosha J Mehta, PhD, Senior Lecturer, Division of Human Sciences, School of Applied Sciences, London South Bank University, 103 Borough Rd, London SE1 0AA, United Kingdom. kosha.mehta@lsbu.ac.uk
Key Words	Iron; Liver pathologies; Liver fibrosis; Hepatic stellate cells; Cirrhosis
Core Tip	Excess iron is observed in several liver pathologies, where it can accelerate the progression of liver fibrosis to cirrhosis and hepatocellular carcinoma, regardless of disease aetiology. This review narrates the role of excess iron in liver fibrosis. It examines the mechanisms by which iron enhances fibrogenic responses and describes various iron-related clinical pathologies. Furthermore, it evaluates the significance of iron and iron-related proteins in the diagnosis and therapeutics of liver fibrosis. The review is unique in that it includes both, cellular mechanisms and clinical aspects of liver fibrosis pertaining to iron. This makes it distinct from previous published reviews.
Citation	Mehta KJ, Farnaud SJ, Sharp PA. Iron and liver fibrosis: Mechanistic and clinical aspects. World J Gastroenterol 2019; 25(5): 521-538

Received	2018-12-02 06:18
Peer-Review Started	2018-12-03 07:14
To Make the First Decision	2018-12-29 01:06
Return for Revision	2018-12-29 02:35
Revised	2019-01-02 08:27
Second Decision	2019-01-04 09:57
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-01-10 05:51
Articles in Press	2019-01-10 05:51
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-01-29 06:57

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved
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