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Publication Name World Journal of Gastroenterology
Manuscript ID 45236
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Characteristics of mucosa-associated gut microbiota during treatment in Crohn’s disease
Manuscript Source Unsolicited Manuscript
All Author List Cong He, Huan Wang, Wang-Di Liao, Chao Peng, Xu Shu, Xuan Zhu and Zhen-Hua zhu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81660101
Special Scientific Research Fund of Public Welfare Profession of National Health and Family Planning Commission 201502026
The Graduate Innovation Fund of Nanchang University CX2017251
Correspondence To Zhen-Hua zhu, PhD, Doctor, Department of Gastroenterology, The First Affiliated Hospital of Nanchang University, 17 Yong Waizheng Street, Donghu District, Nanchang 330006, Jiangxi Province, China. zhuzhenhua19820122@163.com
Keywords Crohn’s disease; Mucosa-associated gut microbiota; Active; Remission; 16S rRNA sequence
Core Tip The dysbiosis of gut microbiome is associated with the development of Crohn’s disease (CD), although the alteration from active CD to remission after treatment is unclear. This study illustrated that the composition of mucosa-associated gut microbiota in active CD significantly changed after the induction of remission regardless of drugs used, which got close to healthy subjects. We speculate that the maintenance of gut microbiota balance may be potential therapeutic target for reducing the risk of disease relapse.
Citation He C, Wang H, Liao WD, Peng C, Shu X, Zhu X, Zhu ZH. Characteristics of mucosa-associated gut microbiota during treatment in Crohn’s disease. World J Gastroenterol 2019; In press
Received
2019-01-06 07:15
Peer-Review Started
2019-01-07 08:45
To Make the First Decision
2019-03-14 06:19
Return for Revision
2019-03-15 02:09
Revised
2019-03-25 07:45
Second Decision
2019-04-04 08:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-04-10 23:28
Articles in Press
2019-04-10 23:28
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 02529129
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 45236-Review.docx
Answering Reviewers 45236-Answering reviewers.pdf
Audio Core Tip 45236-Audio core tip.m4a
Biostatistics Review Certificate 45236-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45236-Conflict-of-interest statement.pdf
Copyright License Agreement 45236-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45236-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 45236-Institutional review board statement.jpg
Non-Native Speakers of English Editing Certificate 45236-Language certificate.pdf
Supplementary Material 45236-Supplementary material.pdf
Peer-review Report 45236-Peer-review(s).pdf
Scientific Misconduct Check 45236-Scientific misconduct check.pdf
Scientific Editor Work List 45236-Scientific editor work list.pdf