Publication Name	World Journal of Hepatology
Manuscript ID	45419
Country	Romania

Category	Surgery
Manuscript Type	Observational Study
Article Title	Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study
Manuscript Source	Invited Manuscript
All Author List	Decebal Fodor, Ioan Jung, Sabin Turdean, Catalin Satala and Simona Gurzu
Funding Agency and Grant Number
Corresponding Author	Simona Gurzu, MD, PhD, Chief Doctor, Doctor, Full Professor, Professor, Department of Pathology, University of Medicine, Pharmacy, Sciences and Technology, 38 Gheorghe Marinescu Street, Targu Mures 540139, Romania. simonagurzu@yahoo.com
Key Words	Hepatocellular carcinoma; Angiogenesis; Endothelial area; Antiangiogenic therapy
Core Tip	In this paper we showed a possible role of morphological and immunohistochemical features of Hepatocellular carcinoma (HCC) in predicting the individualized antiangiogenic therapy of HCC. Based on the results and literature data, it seems that dedifferentiated HCCs developed in non-cirrhotic liver are predominantly driven via Cyclooxygenase-2 axis, whereas vascular endothelial growth factor-A induces hepatocarcinogenesis in patients with HCCs developed on the cirrhosis background.
Citation	Fodor D, Jung I, Turdean S, Satala C, Gurzu S. Angiogenesis of hepatocellular carcinoma: An immunohistochemistry study. World J Hepatol 2019; 11(3): 294-304

Received	2018-12-28 09:26
Peer-Review Started	2018-12-29 01:15
To Make the First Decision	2019-01-25 00:20
Return for Revision	2019-01-27 01:18
Revised	2019-02-22 16:21
Second Decision	2019-03-08 08:15
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-12 15:40
Articles in Press	2019-03-12 15:40
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-27 05:35

ISSN	1948-5182 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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