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3/16/2019 6:01:25 PM | Browse: 257 | Download: 388
Publication Name World Journal of Gastroenterology
Manuscript ID 45484
Country/Territory China
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation
Manuscript Source Unsolicited Manuscript
All Author List Jia-Dong Zheng, Yan He, Heng-Yuan Yu, Yuan-Li Liu, Yi-Xuan Ge, Xue-Ting Li, Xue Li, Yan Wang, Meng-Ru Guo, Yi-Lin Qu, Xiao-Fa Qin, Ming-Shan Jiang and Xiu-Hong Wang
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Foundation of China 81703232
Corresponding Author Xiu-Hong Wang, MSc, PhD, Academic Research, Professor, Department of Biochemistry and Molecular Biology, Heilongjiang Provincial Science and Technology Innovation Team in Higher Education Institutes for Infection and Immunity, Harbin Medical University, 157 Baojian Rd, Harbin 150086, Heilongjiang Province, China. wangxh700417@aliyun.com
Key Words Ulcerative colitis; Unconjugated bilirubin; Intestinal barrier; Intestinal homeostasis; Digestive proteases; Inflammation
Core Tip Intestinal function and microbiota are desired therapeutic endpoints for treatment of inflammatory bowel disease. However, a major problem is the lack of powerful and safe drugs. Unconjugated bilirubin (UCB) has anti-inflammatory and antitoxin effects. We found that UCB significantly decreased intestinal permeability and improved intestinal barrier function; regulated composition of gut microbiota; and relieved intestinal inflammation through suppressing the Toll-like receptor 4/nuclear factor-κB TLR4/NF-κB pathway. This study demonstrated that UCB ameliorates ulcerative colitis via intestinal barrier function through inactivating the digestive proteases and inhibiting immune inflammation through the TLR4/NF-κB signaling pathway.
Citation Zheng JD, He Y, Yu HY, Liu YL, Ge YX, Li XT, Li X, Wang Y, Guo MR, Qu YL, Qin XF, Jiang MS, Wang XH. Unconjugated bilirubin alleviates experimental ulcerative colitis by regulating intestinal barrier function and immune inflammation. World J Gastroenterol 2019; 25(15): 1865-1878
Received
2019-01-04 03:09
Peer-Review Started
2019-01-04 06:51
To Make the First Decision
2019-01-31 06:46
Return for Revision
2019-01-31 08:21
Revised
2019-03-05 07:30
Second Decision
2019-03-15 09:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-16 18:01
Articles in Press
2019-03-16 18:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-03-31 21:09
Typeset the Manuscript
2019-04-17 00:57
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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