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Publication Name World Journal of Gastroenterology
Manuscript ID 45490
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3
Manuscript Source Unsolicited Manuscript
All Author List Yan-Hui Yang, Yu-xiang Zhang, Yang Gui, Jiang-Bo Liu, Jun-Jun Sun and Hua Fan
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China U1504815
the National Natural Science Foundation of China U1504808
Correspondence To Hua Fan, PhD, Academic Fellow, First Affiliated Hospital, College of Clinical Medicine, Henan University of Science and Technology, No. 24 Jing-Hua Road, Luoyang 471003, Henan Province, China. fanhua19851229@haust.edu.cn
Keywords Pancreatic cancer; Autophagy-related protein microtubule-associated protein 1A/1B-light chain 3; Perineural invasion; Gene Ontology analysis; Kyoto Encyclopedia of Genes and Genomes pathway analysis; Ubiquitin C
Core Tip In this study, we identified differentially expressed genes based on the autophagy-related protein microtubule-associated protein 1A/1B-light chain 3 (LC3) to analyze the gene expression profile of autophagy in pancreatic cancer. Three hundred and forty-seven genes that have no confirmed association with the autophagy process of human pancreatic cancer cells in previous studies were concentrated, and the key pathways involved in autophagy were enriched. Furthermore, a key gene ubiquitin C which is closely related to the occurrence of perineural invasion (PNI) was determined, suggesting that LC3 may influence the PNI and prognosis of pancreatic cancer through ubiquitin C.
Citation Yang YH, Zhang YX, Gui Y, Liu JB, Sun JJ, Fan H. Analysis of the autophagy gene expression profile of pancreatic cancer based on autophagy-related protein microtubule-associated protein 1A/1B-light chain 3. World J Gastroenterol 2019; In press
Received
2019-01-09 09:19
Peer-Review Started
2019-01-10 03:26
To Make the First Decision
2019-02-26 07:54
Return for Revision
2019-02-26 09:02
Revised
2019-03-20 07:05
Second Decision
2019-04-04 08:27
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-04-10 22:05
Articles in Press
2019-04-10 22:05
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-22 08:00
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 02742218, and 03104341
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 45490-Review.docx
Answering Reviewers 45490-Answering reviewers.pdf
Audio Core Tip 45490-Audio core tip.mp3
Biostatistics Review Certificate 45490-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 45490-Conflict-of-interest statement.pdf
Copyright License Agreement 45490-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 45490-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 45490-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 45490-Language certificate.pdf
Supplementary Material 45490-Supplementary material.pdf
Peer-review Report 45490-Peer-review(s).pdf
Scientific Misconduct Check 45490-Google-MA RY-1.png
Scientific Misconduct Check 45490-Google-MA RY-2.png
Scientific Misconduct Check 45490-Scientific misconduct check.pdf
Scientific Editor Work List 45490-Scientific editor work list.pdf