Publication Name	World Journal of Gastroenterology
Manuscript ID	45590
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Xiao-Hong Xiang, Li Yang, Xing Zhang, Xiao-Hua Ma, Run-Chen Miao, Jing-Xian Gu, Yu-Nong Fu, Qing Yao, Jing-Yao Zhang, Chang Liu, Ting Lin and Kai Qu
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81773128 the National Natural Science Foundation of China 81871998 the Natural Science Basic Research Plan in Shaanxi Province of China 2018JM7013 the Natural Science Basic Research Plan in Shaanxi Province of China 2017JM8039 the Research Fund for Young Star of Science and Technology in Shaanxi Province 2018KJXX-022 China Postdoctoral Science Foundation 2018M641000
Corresponding Author	Kai Qu, MD, PhD, Professor, Research Assistant Professor, Department of Hepatobiliary Surgery, the First Affiliated Hospital of Xi’an Jiaotong University, West Yanta Road 277, Xi'an 710061, Shaanxi Province, China. qukaixjtu@163.com
Key Words	Senescence-associated genes; Hepatocellular carcinoma; Overall survival; Risk model; Asian patients
Core Tip	In the present study, we identified a total of 42 senescence-associated genes (SAGs) and found seven of them were significantly downregulated in senescent cells and upregulated in HCC tissues. By using the least absolute shrinkage and selection operator, we constructed a seven-SAG signature that could predict the overall survival (OS) of hepatocellular carcinoma. This seven-SAG signature was further validated and developed in another independent dataset from The Cancer Genome Atlas project. Moreover, our risk score system showed better utility in predicting the OS than classic serum biomarker α-fetoprotein.
Citation	Xiang XH, Yang L, Zhang X, Ma XH, Miao RC, Gu JX, Fu YN, Yao Q, Zhang JY, Liu C, Lin T, Qu K. Seven-senescence-associated gene signature predicts overall survival for Asian patients with hepatocellular carcinoma. World J Gastroenterol 2019; 25(14): 1715-1728

Received	2019-01-06 07:17
Peer-Review Started	2019-01-07 10:31
To Make the First Decision	2019-02-14 01:04
Return for Revision	2019-02-15 03:10
Revised	2019-03-06 06:45
Second Decision	2019-03-15 09:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-16 18:00
Articles in Press	2019-03-16 18:00
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-03-25 14:14
Typeset the Manuscript	2019-04-10 10:09

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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