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Publication Name World Journal of Clinical Oncology
Manuscript ID 45740
Country of Manuscript Source Romania
Specialty Oncology
Manuscript type Review
Article Title Malignant hepatic vascular tumors in adults: Characteristics, diagnostic difficulties and current management
Manuscript Source Invited Manuscript
All Author List Daniela Cornelia Lazăr, Mihaela Flavia Avram, Ioan Romoșan, Violetta Vacariu, Adrian Goldiș and Mărioara Cornianu
Funding Agency and Grant Number
Correspondence To Mihaela Flavia Avram, MD, PhD, Assistant Professor, Doctor, Surgeon, Department of Surgery X, 1st Surgery Clinic, University of Medicine and Pharmacy “Victor Babeş”, Piata Eftimie Murgu No. 2, Timisoara 300041, Romania. avram.mihaela@umft.ro
Keywords Hepatic malignant vascular tumors; Hepatic small vessel neoplasia; Hepatic perivascular epithelioid cell tumor; Hepatic hemangiopericytoma; Hepatic epithelioid hemangioendothelioma; Kaposi sarcoma; Hepatic angiosarcoma; Diagnostic; Prognostic; Treatment
Core Tip Primary malignant vascular tumors of the liver are rare mesenchymal tumors, most commonly detected incidentally using modern imaging techniques. They have variable clinical and imaging features, histology, immunohistochemistry, and molecular findings; therefore, their diagnosis may be difficult. Surgery represents the mainstay of treatment. Hepatic angiosarcoma has a dismal outcome and represents a contraindication for liver transplantation. Development of novel antiangiogenic and other molecular targeted treatments are needed to improve the patient outcome. This paper provides an overview of this group of tumors based on the most recent literature data, encompassing modern information regarding diagnostic challenges, prognostic factors and perspective therapeutic approaches.
Citation Lazăr DC, Avram MF, Romosan I, Văcariu V, Goldis A, Cornianu M. Malignant hepatic vascular tumors in adults: Characteristics, diagnostic difficulties and current management. World J Clin Oncol 2019; 10(3): 110-135
Received
2019-01-13 06:38
Peer-Review Started
2019-01-14 00:34
To Make the First Decision
2019-01-28 06:15
Return for Revision
2019-01-29 00:52
Revised
2019-02-23 16:29
Second Decision
2019-03-07 09:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 22:09
Articles in Press
2019-03-12 22:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-03-22 06:53
ISSN 2218-4333 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 02509032, 02731847, and 03769383
Editorial Director Fang-Fang Ji
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor Yun-Xiaojian Wu
Responsible Electronic Editor Yun-Xiaojian Wu
Responsible Science Editor Jin-Lei Wang
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJCO-10-110.pdf
Full Article (Word) WJCO-10-110.docx
Manuscript File 45740-Review.docx
Answering Reviewers 45740-Answering reviewers.pdf
Audio Core Tip 45740-Audio core tip.m4a
Conflict-of-Interest Disclosure Form 45740-Conflict-of-interest statement.pdf
Copyright License Agreement 45740-Copyright license agreement.pdf
Non-Native Speakers of English Editing Certificate 45740-Language certificate.pdf
Peer-review Report 45740-Peer-review(s).pdf
Scientific Misconduct Check 45740-Scientific misconduct check.pdf
Scientific Editor Work List 45740-Scientific editor work list.pdf