Publication Name	World Journal of Clinical Oncology
Manuscript ID	45740
Country	Romania

Category	Oncology
Manuscript Type	Review
Article Title	Malignant hepatic vascular tumors in adults: Characteristics, diagnostic difficulties and current management
Manuscript Source	Invited Manuscript
All Author List	Daniela Cornelia Lazăr, Mihaela Flavia Avram, Ioan Romoșan, Violetta Vacariu, Adrian Goldiș and Mărioara Cornianu
Funding Agency and Grant Number
Corresponding Author	Mihaela Flavia Avram, MD, PhD, Assistant Professor, Doctor, Doctor, Surgeon, Department of Surgery X, 1st Surgery Clinic, University of Medicine and Pharmacy “Victor Babeş”, Piata Eftimie Murgu No. 2, Timisoara 300041, Romania. avram.mihaela@umft.ro
Key Words	Hepatic malignant vascular tumors; Hepatic small vessel neoplasia; Hepatic perivascular epithelioid cell tumor; Hepatic hemangiopericytoma; Hepatic epithelioid hemangioendothelioma; Kaposi sarcoma; Hepatic angiosarcoma; Diagnostic; Prognostic; Treatment
Core Tip	Primary malignant vascular tumors of the liver are rare mesenchymal tumors, most commonly detected incidentally using modern imaging techniques. They have variable clinical and imaging features, histology, immunohistochemistry, and molecular findings; therefore, their diagnosis may be difficult. Surgery represents the mainstay of treatment. Hepatic angiosarcoma has a dismal outcome and represents a contraindication for liver transplantation. Development of novel antiangiogenic and other molecular targeted treatments are needed to improve the patient outcome. This paper provides an overview of this group of tumors based on the most recent literature data, encompassing modern information regarding diagnostic challenges, prognostic factors and perspective therapeutic approaches.
Citation	Lazăr DC, Avram MF, Romosan I, Văcariu V, Goldis A, Cornianu M. Malignant hepatic vascular tumors in adults: Characteristics, diagnostic difficulties and current management. World J Clin Oncol 2019; 10(3): 110-135

Received	2019-01-13 06:38
Peer-Review Started	2019-01-14 00:34
To Make the First Decision	2019-01-28 06:15
Return for Revision	2019-01-29 00:52
Revised	2019-02-23 16:29
Second Decision	2019-03-07 09:28
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2019-03-12 22:09
Articles in Press	2019-03-12 22:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-22 06:53

ISSN	2218-4333 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com