Publication Name	World Journal of Gastroenterology
Manuscript ID	45986
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Proteomics of the mediodorsal thalamic nucleus of stress-induced gastriculcer rat
Manuscript Source	Unsolicited Manuscript
All Author List	Sheng-Nan Gong, Jian-Ping Zhu, Ying-Jie Ma and Dong-Qin Zhao
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China No. 31501861 the Natural Science Foundation of Shandong Province, China No. ZR2015CM013
Corresponding Author	Dong-Qin Zhao, PhD, Associate Professor, Teacher, College of Life Sciences, Shandong Normal University, No. 88 East Wenhua Road, Lixia District, Jinan 250014, Shandong Province, China. zhaodq@sdnu.edu.cn
Key Words	Mediodorsal thalamic nucleus; Proteome; Restraint-water-immersion-stress; Stress-induced gastric ulcer; Glycogen synthase kinase-3 beta
Core Tip	Quantitative proteomic analysis was used to screen for differentially expressed proteins in the mediodorsal thalamic nucleus of rats subjected to a restraint water-immersion stress state. A total of 65 dysregulated proteins were identified, which were mainly involved in the neurological disease signalling pathways. Meanwhile, the 31 upregulated proteins were primarily related to cell division, whereas the 34 downregulated proteins were related to neuron morphogenesis and neurotransmitter regulation. Furthermore, glycogen synthase kinase-3 beta might be related to the central mechanism through which restraint-water-immersion-stress gives rise to stress-induced gastric ulcer (SGU). Proteomic analysis elucidated the nervous system molecular targets of SGU.
Citation	Gong SN, Zhu JP, Ma YJ, Zhao DQ. Proteomics of the mediodorsal thalamic nucleus of stress-induced gastriculcer rat. World J Gastroenterol 2019; 25(23): 2911-2923

Received	2019-01-27 02:01
Peer-Review Started	2019-01-27 03:01
To Make the First Decision	2019-03-20 06:34
Return for Revision	2019-03-20 08:20
Revised	2019-05-08 06:27
Second Decision	2019-05-17 08:51
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-18 12:52
Articles in Press	2019-05-18 12:52
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-05-24 00:57
Typeset the Manuscript	2019-06-19 05:47

ISSN	1007-9327 (print) and 2219-2840 (online)
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