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Publication Name World Journal of Gastroenterology
Manuscript ID 46143
Country of Manuscript Source Japan
Specialty Gastroenterology and Hepatology
Manuscript type Observational Study
Article Title Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations
Manuscript Source Unsolicited Manuscript
All Author List Yuichi Matsuno, Junji Umeno, Motohiro Esaki, Yoichiro Hirakawa, Yuta Fuyuno, Yasuharu Okamoto, Atsushi Hirano, Shigeyoshi Yasukawa, Fumihito Hirai, Toshiyuki Matsui, Shuhei Hosomi, Kenji Watanabe, Naoki Hosoe, Haruhiko Ogata, Tadakazu Hisamatsu, Shunichi Yanai, Shuji Kochi, Koichi Kurahara, Tsuneyoshi Yao, Takehiro Torisu, Takanari Kitazono and Takayuki Matsumoto
Funding Agency and Grant Number
Funding Agency Grant Number
the Practical Research Project for Rare/Intractable Diseases from the Japan Agency for Medical Research and Development 15ek0109053h0002
Japan Society for the Promotion of Science (JSPS) KAKENHI 25460953
Correspondence To Takayuki Matsumoto, MD, PhD, Professor, Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. tmatsumo@iwate-med.ac.jp
Keywords Chronic enteropathy associated with SLCO2A1 gene; Prostaglandin E major urinary metabolites; Chronic nonspecific multiple ulcers of the small intestine; Crohn’s disease; Small intestine
Core Tip Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary enteropathy associated with a gene encoding a prostaglandin transporter. It is sometimes difficult to distinguish CEAS from Crohn’s disease (CD), because these diseases share some clinical features. We report the usefulness of prostaglandin E-major urinary metabolites (PGE-MUM) to differentiate CEAS from CD. PGE-MUM concentration was significantly higher in CEAS than in CD, and optimal cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with sensitivity of 95.0% and specificity of 79.6%. In clinical practice, PGE-MUM measurement might be useful as a screening test for CEAS.
Citation Matsuno Y, Umeno J, Esaki M, Hirakawa Y, Fuyuno Y, Okamoto Y, Hirano A, Yasukawa S, Hirai F, Matsui T, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Yanai S, Kochi S, Kurahara K, Yao T, Torisu T, Kitazono T, Matsumoto T. Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations. World J Gastroenterol 2019; In press
Received
2019-02-03 14:21
Peer-Review Started
2019-02-06 05:25
To Make the First Decision
2019-02-21 03:37
Return for Revision
2019-02-22 02:28
Revised
2019-02-27 12:09
Second Decision
2019-03-08 08:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 02:14
Articles in Press
2019-03-12 02:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 00058401, 01221925, and 00503623
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 46143-Review.docx
Answering Reviewers 46143-Answering reviewers.pdf
Audio Core Tip 46143-Audio core tip.mp3
Biostatistics Review Certificate 46143-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46143-Conflict-of-interest statement.pdf
Copyright License Agreement 46143-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46143-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 46143-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 46143-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 46143-Language certificate.pdf
Supplementary Material 46143-Supplementary material.pdf
Peer-review Report 46143-Peer-review(s).pdf
Scientific Misconduct Check 46143-Scientific misconduct check.pdf
Scientific Editor Work List 46143-Scientific editor work list.pdf