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Publication Name World Journal of Gastroenterology
Manuscript ID 46143
Country/Territory Japan
Category Gastroenterology & Hepatology
Manuscript Type Observational Study
Article Title Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations
Manuscript Source Unsolicited Manuscript
All Author List Yuichi Matsuno, Junji Umeno, Motohiro Esaki, Yoichiro Hirakawa, Yuta Fuyuno, Yasuharu Okamoto, Atsushi Hirano, Shigeyoshi Yasukawa, Fumihito Hirai, Toshiyuki Matsui, Shuhei Hosomi, Kenji Watanabe, Naoki Hosoe, Haruhiko Ogata, Tadakazu Hisamatsu, Shunichi Yanai, Shuji Kochi, Koichi Kurahara, Tsuneyoshi Yao, Takehiro Torisu, Takanari Kitazono and Takayuki Matsumoto
Funding Agency and Grant Number
Funding Agency Grant Number
the Practical Research Project for Rare/Intractable Diseases from the Japan Agency for Medical Research and Development 15ek0109053h0002
Japan Society for the Promotion of Science (JSPS) KAKENHI 25460953
Corresponding Author Takayuki Matsumoto, MD, PhD, Professor, Division of Gastroenterology, Department of Internal Medicine, Iwate Medical University, 19-1 Uchimaru, Morioka 020-8505, Japan. tmatsumo@iwate-med.ac.jp
Key Words Chronic enteropathy associated with SLCO2A1 gene; Prostaglandin E major urinary metabolites; Chronic nonspecific multiple ulcers of the small intestine; Crohn’s disease; Small intestine
Core Tip Chronic enteropathy associated with SLCO2A1 gene (CEAS) is a rare hereditary enteropathy associated with a gene encoding a prostaglandin transporter. It is sometimes difficult to distinguish CEAS from Crohn’s disease (CD), because these diseases share some clinical features. We report the usefulness of prostaglandin E-major urinary metabolites (PGE-MUM) to differentiate CEAS from CD. PGE-MUM concentration was significantly higher in CEAS than in CD, and optimal cut-off value for the distinction of CEAS from CD to be 48.9 μg/g × Cre with sensitivity of 95.0% and specificity of 79.6%. In clinical practice, PGE-MUM measurement might be useful as a screening test for CEAS.
Citation Matsuno Y, Umeno J, Esaki M, Hirakawa Y, Fuyuno Y, Okamoto Y, Hirano A, Yasukawa S, Hirai F, Matsui T, Hosomi S, Watanabe K, Hosoe N, Ogata H, Hisamatsu T, Yanai S, Kochi S, Kurahara K, Yao T, Torisu T, Kitazono T, Matsumoto T. Measurement of prostaglandin metabolites is useful in diagnosis of small bowel ulcerations. World J Gastroenterol 2019; 25(14): 1753-1763
Received
2019-02-03 14:21
Peer-Review Started
2019-02-06 05:25
To Make the First Decision
2019-02-21 03:37
Return for Revision
2019-02-22 02:28
Revised
2019-02-27 12:09
Second Decision
2019-03-08 08:17
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 02:14
Articles in Press
2019-03-12 02:14
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-04-04 11:06
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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