Publication Name	World Journal of Clinical Cases
Manuscript ID	46157
Country	China

Category	Medicine, Research & Experimental
Manuscript Type	Case Report
Article Title	Novel ATL1 mutation in a Chinese family with hereditary spastic paraplegia: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Xue-Wen Xiao, Juan Du, Bin Jiao, Xin-Xin Liao, Lu Zhou, Xi-Xi Liu, Zhen-Hua Yuan, Li-Na Guo, Xin Wang, Lu Shen and Zhang-Yuan Lin
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81171068
Corresponding Author	Zhang-Yuan Lin, MD, PhD, Surgeon, Department of Orthopedics, Xiangya Hospital, Central South University, No. 87 Xiangya Rd., Kaifu District, Changsha 410008, Hunan Province, China. linzhangyuan2505@sina.com
Key Words	Hereditary spastic paraplegia; SPG3A; Atlastin-1 (ATL1) gene; Hearing loss; Case report
Core Tip	Hereditary spastic paraplegias are a group of genetically and clinically heterogeneous neurodegenerative diseases characterized by lower limbs spasticity and weakness. Here we reported a novel ATL1 Q251R mutation predicted to be pathogenic and a novel clinical phenotype of hearing loss in a Chinese SPG3A family, which expands the clinical and genetic spectrum of ATL1 mutations.
Citation	Xiao XW, Du J, Jiao B, Liao XX, Zhou L, Liu XX, Yuan ZH, Guo LN, Wang X, Shen L, Lin ZY. Novel ATL1 mutation in a Chinese family with hereditary spastic paraplegia: A case report and review of literature. World J Clin Cases 2019; 7(11): 1358-1366

Received	2019-02-02 07:23
Peer-Review Started	2019-02-11 01:30
To Make the First Decision	2019-03-14 00:14
Return for Revision	2019-03-19 03:12
Revised	2019-03-23 05:36
Second Decision	2019-03-28 00:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-09 18:12
Articles in Press	2019-04-09 18:12
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-05 10:01

ISSN	2307-8960 (online)
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