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Publication Name World Journal of Transplantation
Manuscript ID 46301
Country of Manuscript Source United States
Specialty Transplantation
Manuscript type Meta-Analysis
Article Title Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis
Manuscript Source Invited Manuscript
All Author List Boonphiphop Boonpheng, Charat Thongprayoon, Tarun Bathini, Konika Sharma, Michael A Mao and Wisit Cheungpasitporn
Funding Agency and Grant Number
Correspondence To Wisit Cheungpasitporn, MD, Assistant Professor, Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS 39216, United States. wcheungpasitporn@gmail.com
Keywords Proton pump inhibitors; Kidney; Renal transplantation; Meta-analysis hypomagnesemia; Systematic reviews
Core Tip Several pharmacokinetic studies have raised concerns regarding the interaction between proton pump inhibitors (PPIs) and immunosuppressive drugs in transplant patients. Whether the adverse effects of PPIs have a clinical significance in kidney transplant recipients remains unclear. We performed this meta-analysis to assess the risk of adverse effects in kidney transplant recipients on PPI compared with those without PPI exposure. We demonstrate that PPI use is not associated with significant risks of higher acute rejection, graft loss, or 1-year mortality. However, PPI use is associated with 1.56-fold increased risk of hypomagnesemia. Thus, future studies are needed to assess the impact of PPIs on long-term outcomes.
Citation Boonpheng B, Thongprayoon C, Bathini T, Sharma K, Mao MA, Cheungpasitporn W. Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis. World J Transplantation 2019; In press
Received
2019-02-06 04:03
Peer-Review Started
2019-02-12 05:02
To Make the First Decision
2019-03-18 06:33
Return for Revision
2019-03-26 11:25
Revised
2019-03-26 23:19
Second Decision
2019-05-10 08:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-05-14 10:06
Articles in Press
2019-05-14 10:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 2220-3230 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 03742333, and 03291363
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 46301-Review.docx
Answering Reviewers 46301-Answering reviewers.pdf
Audio Core Tip 46301-Audio core tip.mp3
Biostatistics Review Certificate 46301-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46301-Conflict-of-interest statement.pdf
Copyright License Agreement 46301-Copyright license agreement.pdf
Supplementary Material 46301-Supplementary material.pdf
Peer-review Report 46301-Peer-review(s).pdf
Scientific Misconduct Check 46301-Scientific misconduct check.pdf
Scientific Editor Work List 46301-Scientific editor work list.pdf