Publication Name	World Journal of Transplantation
Manuscript ID	46301
Country	United States

Category	Transplantation
Manuscript Type	Meta-Analysis
Article Title	Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis
Manuscript Source	Invited Manuscript
All Author List	Boonphiphop Boonpheng, Charat Thongprayoon, Tarun Bathini, Konika Sharma, Michael A Mao and Wisit Cheungpasitporn
Funding Agency and Grant Number
Corresponding Author	Wisit Cheungpasitporn, MD, Assistant Professor, Division of Nephrology, Department of Medicine, University of Mississippi Medical Center, 2500 N. State St., Jackson, MS 39216, United States. wcheungpasitporn@gmail.com
Key Words	Proton pump inhibitors; Kidney; Renal transplantation; Meta-analysis hypomagnesemia; Systematic reviews
Core Tip	Several pharmacokinetic studies have raised concerns regarding the interaction between proton pump inhibitors (PPIs) and immunosuppressive drugs in transplant patients. Whether the adverse effects of PPIs have a clinical significance in kidney transplant recipients remains unclear. We performed this meta-analysis to assess the risk of adverse effects in kidney transplant recipients on PPI compared with those without PPI exposure. We demonstrate that PPI use is not associated with significant risks of higher acute rejection, graft loss, or 1-year mortality. However, PPI use is associated with 1.56-fold increased risk of hypomagnesemia. Thus, future studies are needed to assess the impact of PPIs on long-term outcomes.
Citation	Boonpheng B, Thongprayoon C, Bathini T, Sharma K, Mao MA, Cheungpasitporn W. Proton pump inhibitors and adverse effects in kidney transplant recipients: A meta-analysis. World J Transplantation 2019; 9(2): 35-47

Received	2019-02-06 04:03
Peer-Review Started	2019-02-12 05:02
To Make the First Decision	2019-03-18 06:33
Return for Revision	2019-03-26 11:25
Revised	2019-03-26 23:19
Second Decision	2019-05-10 08:24
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-14 10:06
Articles in Press	2019-05-14 10:06
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-24 01:53

ISSN	2220-3230 (online)
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