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Publication Name World Journal of Gastroenterology
Manuscript ID 46380
Country of Manuscript Source Germany
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Study
Article Title Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis
Manuscript Source Unsolicited Manuscript
All Author List Peter Hoffmann, Cyrill Wehling, Johannes Krisam, Jan Pfeiffenberger, Nina Belling and Annika Gauss
Funding Agency and Grant Number
Correspondence To Annika Gauss, MD, Assistant Professor, Doctor, Department of Gastroenterology and Hepatology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg 69120, Germany. annika.gauss@med.uni-heidelberg.de
Keywords Acute severe ulcerative colitis; Steroid-refractory; Tacrolimus; Rescue therapy; Calcineurin inhibitor; Inflammatory bowel disease; Hospitalized
Core Tip Steroid-refractory acute severe ulcerative colitis requires hospitalization and is frequently a risky tightrope walk between surgery and medical treatment. Whereas sufficient data has been provided over time to justify ciclosporin and infliximab as salvage therapies in this clinical scenario, guideline recommendations are still more reluctant towards tacrolimus due to the relative lack of data. However, tacrolimus may have advantages over ciclosporin especially due to its different toxicity profile. Our study provides more insight in the potential of tacrolimus in the strictly defined situation of steroid-refractory acute severe ulcerative colitis in hospitalized patients.
Citation Hoffmann P, Wehling C, Krisam J, Pfeiffenberger J, Belling N, Gauss A. Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis. World J Gastroenterol 2019; In press
Received
2019-02-14 08:09
Peer-Review Started
2019-02-17 09:50
To Make the First Decision
2019-02-21 03:36
Return for Revision
2019-02-22 03:29
Revised
2019-02-23 15:50
Second Decision
2019-03-08 08:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-03-12 01:37
Articles in Press
2019-03-12 01:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 00503322, 00505564, and 02566971
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 46380-Review.docx
Answering Reviewers 46380-Answering reviewers.pdf
Audio Core Tip 46380-Audio core tip.mp3
Biostatistics Review Certificate 46380-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46380-Conflict-of-interest statement.pdf
Copyright License Agreement 46380-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 46380-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 46380-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 46380-Language certificate.pdf
Peer-review Report 46380-Peer-review(s).pdf
Scientific Misconduct Check 46380-Scientific misconduct check.pdf
Scientific Editor Work List 46380-Scientific editor work list.pdf