Publication Name	World Journal of Gastroenterology
Manuscript ID	46380
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis
Manuscript Source	Unsolicited Manuscript
All Author List	Peter Hoffmann, Cyrill Wehling, Johannes Krisam, Jan Pfeiffenberger, Nina Belling and Annika Gauss
Funding Agency and Grant Number
Corresponding Author	Annika Gauss, MD, Assistant Professor, Doctor, Department of Gastroenterology and Hepatology, Heidelberg University Hospital, Im Neuenheimer Feld 410, Heidelberg 69120, Germany. annika.gauss@med.uni-heidelberg.de
Key Words	Acute severe ulcerative colitis; Steroid-refractory; Tacrolimus; Rescue therapy; Calcineurin inhibitor; Inflammatory bowel disease; Hospitalized
Core Tip	Steroid-refractory acute severe ulcerative colitis requires hospitalization and is frequently a risky tightrope walk between surgery and medical treatment. Whereas sufficient data has been provided over time to justify ciclosporin and infliximab as salvage therapies in this clinical scenario, guideline recommendations are still more reluctant towards tacrolimus due to the relative lack of data. However, tacrolimus may have advantages over ciclosporin especially due to its different toxicity profile. Our study provides more insight in the potential of tacrolimus in the strictly defined situation of steroid-refractory acute severe ulcerative colitis in hospitalized patients.
Citation	Hoffmann P, Wehling C, Krisam J, Pfeiffenberger J, Belling N, Gauss A. Performance of tacrolimus in hospitalized patients with steroid-refractory acute severe ulcerative colitis. World J Gastroenterol 2019; 25(13): 1603-1617

Received	2019-02-14 08:09
Peer-Review Started	2019-02-17 09:50
To Make the First Decision	2019-02-21 03:36
Return for Revision	2019-02-22 03:29
Revised	2019-02-23 15:50
Second Decision	2019-03-08 08:23
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-12 01:37
Articles in Press	2019-03-12 01:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-04-01 07:10

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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