Publication Name	World Journal of Meta-Analysis
Manuscript ID	46560
Country	Japan

Category	Medicine, Research & Experimental
Manuscript Type	Review
Article Title	Prospects for immunotherapy as a novel therapeutic strategy against hepatocellular carcinoma
Manuscript Source	Invited Manuscript
All Author List	Yu Akazawa, Toshihiro Suzuki, Toshiaki Yoshikawa, Shoichi Mizuno, Yasunari Nakamoto and Tetsuya Nakatsura
Funding Agency and Grant Number
Corresponding Author	Tetsuya Nakatsura, MD, PhD, Doctor, Professor, Division of Cancer Immunotherapy, Exploratory Oncology Research and Clinical Trial Center, National Cancer Center, 6-5-1 Kashiwanoha, Kashiwa 277-8577, Japan. tnakatsu@east.ncc.go.jp
Key Words	Hepatocellular carcinoma; Cancer immunotherapy; Immune checkpoint inhibitor; Glypican-3; Cancer vaccine; Clinical trials; Cytotoxic T-lymphocytes
Core Tip	Hepatocellular carcinoma (HCC) is a highly aggressive malignant disease, with a poor prognosis. Recent developments and advances in cancer immunotherapy, particularly immune checkpoint inhibitor therapy, could lead to a major paradigm shift in standard HCC therapy. This review aims to provide an overview of novel immunotherapies, including antigen-based immunotherapies such as glypican-3-targeted immunotherapy, and immune checkpoint inhibitor therapy against HCC. It also discusses the future prospects of cancer immunotherapy against HCC.
Citation	Akazawa Y, Suzuki T, Yoshikawa T, Mizuno S, Nakamoto Y, Nakatsura T. Prospects for immunotherapy as a novel therapeutic strategy against hepatocellular carcinoma. World J Meta-Anal 2019; 7(3): 80-95

Received	2019-02-20 07:42
Peer-Review Started	2019-02-20 09:19
To Make the First Decision	2019-03-07 05:59
Return for Revision	2019-03-07 06:24
Revised	2019-03-12 08:21
Second Decision	2019-03-15 09:49
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-03-16 22:34
Articles in Press	2019-03-16 22:34
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-03-29 03:11

ISSN	2308-3840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com