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4/9/2019 8:59:39 PM | Browse: 143 | Download: 22
Publication Name World Journal of Clinical Cases
Manuscript ID 46797
Country of Manuscript Source Italy
Specialty Medicine, Research and Experimental
Manuscript type Retrospective Cohort Study
Article Title Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values
Manuscript Source Invited Manuscript
All Author List Pierluigi Marzuillo, Stefano Guarino, Tiziana Esposito, Anna Di Sessa, Sara Immacolata Orsini, Daniela Capalbo, Emanuele Miraglia del Giudice and Angela La Manna
Funding Agency and Grant Number
Correspondence To Pierluigi Marzuillo, MD, PhD, Doctor, Postdoc, Postdoctoral Fellow, Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 2, Naples 80138, Italy. pierluigi.marzuillo@gmail.com
Keywords Nephrotic syndrome; Rituximab; IgG hypogammaglobulinemia; Immunoglobulin
Core Tip It has been shown in pediatric patients with complicated nephrotic syndrome (NS) that rituximab (RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal IgG levels. Our case series shows that RTX can induce IgG hypogammaglobulinemia also in patients with pre-RTX IgG normal values and that persisting IgG hypogammaglobulinemia could be dose-dependent. When evaluating a patient with complicated NS and post-RTX IgG hypogammaglobulinemia, the IgG supplementation could not be needed because, until now, no severe infections have been detected and the possibility of adverse events related to IgG supplementation exists.
Citation Marzuillo P, Guarino S, Esposito T, Di Sessa A, Orsini SI, Capalbo D, Miraglia del Giudice E, La Manna A. Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values. World J Clin Cases 2019; In press
Received
2019-02-25 01:23
Peer-Review Started
2019-02-26 00:29
To Make the First Decision
2019-03-14 00:14
Return for Revision
2019-03-19 02:47
Revised
2019-03-20 15:57
Second Decision
2019-03-28 00:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-04-09 20:59
Articles in Press
2019-04-09 20:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-04-16 17:08
Typeset the Manuscript
ISSN 2307-8960 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Fang-Fang Ji
Reviewer Code 00503257, 00503179, and 00503199
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Donna Fox
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File FP6821_de5_CE1MS-edit2-2-3.doc
Answering Reviewers 46797-Answering reviewers.pdf
Audio Core Tip 46797-Audio core tip.mp3
Biostatistics Review Certificate 46797-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46797-Conflict-of-interest statement.pdf
Copyright License Agreement 46797-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 46797-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 46797-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 46797-Language certificate.pdf
Peer-review Report 46797-Peer-review(s).pdf
Scientific Misconduct Check 46797-Scientific misconduct check.pdf
Scientific Editor Work List 46797-Scientific editor work list.pdf