Publication Name	World Journal of Clinical Cases
Manuscript ID	46797
Country	Italy

Category	Medicine, Research & Experimental
Manuscript Type	Retrospective Cohort Study
Article Title	Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values
Manuscript Source	Invited Manuscript
All Author List	Pierluigi Marzuillo, Stefano Guarino, Tiziana Esposito, Anna Di Sessa, Sara Immacolata Orsini, Daniela Capalbo, Emanuele Miraglia del Giudice and Angela La Manna
Funding Agency and Grant Number
Corresponding Author	Pierluigi Marzuillo, MD, PhD, Doctor, Postdoc, Postdoctoral Fellow, Department of Woman, Child and of General and Specialized Surgery, Università degli Studi della Campania “Luigi Vanvitelli”, Via Luigi De Crecchio 2, Naples 80138, Italy. pierluigi.marzuillo@gmail.com
Key Words	Nephrotic syndrome; Rituximab; IgG hypogammaglobulinemia; Immunoglobulin
Core Tip	It has been shown in pediatric patients with complicated nephrotic syndrome (NS) that rituximab (RTX) administration can induce persistent IgG hypogammaglobulinemia among subjects showing low basal IgG levels. Our case series shows that RTX can induce IgG hypogammaglobulinemia also in patients with pre-RTX IgG normal values and that persisting IgG hypogammaglobulinemia could be dose-dependent. When evaluating a patient with complicated NS and post-RTX IgG hypogammaglobulinemia, the IgG supplementation could not be needed because, until now, no severe infections have been detected and the possibility of adverse events related to IgG supplementation exists.
Citation	Marzuillo P, Guarino S, Esposito T, Di Sessa A, Orsini SI, Capalbo D, Miraglia del Giudice E, La Manna A. Rituximab-induced IgG hypogammaglobulinemia in children with nephrotic syndrome and normal pre-treatment IgG values. World J Clin Cases 2019; 7(9): 1021-1027

Received	2019-02-25 01:23
Peer-Review Started	2019-02-26 00:29
To Make the First Decision	2019-03-14 00:14
Return for Revision	2019-03-19 02:47
Revised	2019-03-20 15:57
Second Decision	2019-03-28 00:53
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-09 20:59
Articles in Press	2019-04-09 20:59
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-04-16 17:08
Typeset the Manuscript	2019-05-06 04:44

ISSN	2307-8960 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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