Publication Name	World Journal of Diabetes
Manuscript ID	46810
Country	Iran

Category	Endocrinology & Metabolism
Manuscript Type	Observational Study
Article Title	Different metabolic/obesity phenotypes are differently associated with developing of pre-diabetes in adults: Results from a 14-year cohort study
Manuscript Source	Invited Manuscript
All Author List	Fahimeh Haghighatdoost, Masoud Amini, Ashraf Aminorroaya, Majid Abyar and Awat Feizi
Funding Agency and Grant Number
Corresponding Author	Awat Feizi, PhD, Professor, Biostatistics and Epidemiology Department, School of Health, Isfahan University of Medical Sciences, P.O. Box 319, Hezar-Jerib Ave, Isfahan 81746-73461, Iran. awat_feiz@hlth.mui.ac.ir
Key Words	Prediabetes; Obesity; Metabolic status; Cohort study
Core Tip	The risk of developing prediabetes based on the metabolic/obesity phenotypes has been poorly investigated. In a 14-year follow-up cohort study, we observed that metabolically unhealthy normal weight, metabolically healthy obese (MHO), and metabolically unhealthy obese (MUO) were at higher risk for developing prediabetes compared with metabolically healthy normal weight (MHNW) subjects. The results stratified by sex demonstrated no significant association in men, whilst in women the risk of prediabetes development was significantly higher in all metabolic/obesity phenotypes compared with MHNW. Transforming from each phenotype to MHNW or MHO was not related to the risk of prediabetes development, whereas transforming from each phenotype to MUO was associated with increased risk of prediabetes.
Citation	Haghighatdoost F, Amini M, Aminorroaya A, Abyar M, Feizi A. Different metabolic/obesity phenotypes are differently associated with developing of pre-diabetes in adults: Results from a 14-year cohort study. World J Diabetes 2019; 10(6): 350-361

Received	2019-02-24 10:41
Peer-Review Started	2019-02-26 00:44
To Make the First Decision	2019-03-11 03:45
Return for Revision	2019-03-11 09:11
Revised	2019-05-10 07:21
Second Decision	2019-05-13 10:37
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-14 01:33
Articles in Press	2019-05-14 01:33
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-05-22 23:57
Typeset the Manuscript	2019-06-12 09:00

ISSN	1948-9358 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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