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Publication Name World Journal of Gastroenterology
Manuscript ID 46893
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Berberine prevents stress-induced gut inflammation, visceral hypersensitivity and reduces intestinal motility in rats
Manuscript Source Unsolicited Manuscript
All Author List Zhi-Chao Yu, Yong-Xin Cen, Ben-Hua Wu, Cheng Wei, Feng Xiong, De-Feng Li, Ting-Ting Liu, Ming-Han Luo, Li-Liangzi Guo, Ying-Xue Li, Li-Sheng Wang, Jian-Yao Wang and Jun Yao
Funding Agency and Grant Number
Funding Agency Grant Number
the National Natural Science Foundation of China 81800489
Three engineering training funds in Shenzhen SYLY201718
Technical Research and Development Project of Shenzhen JCYJ20170307100538697
Technical Research and Development Project of Shenzhen JCYJ20160429174927286
Technical Research and Development Project of Shenzhen JCYJ20170307100911479
Correspondence To Jun Yao, MD, PhD, Doctor, Department of Gastroenterology, Jinan University of Second Clinical Medical Sciences, Shenzhen Municipal People’s Hospital, 1017 East Gate Road, Shenzhen 518020, Guangdong Province, China. YJ_1108@126.com
Keywords Irritable bowel syndrome; Visceral hypersensitivity; Berberine; Rifampicin; Nuclear factor kappa-B; Brain-derived neurotrophic factor
Core Tip Irritable bowel syndrome (IBS) is a common chronic non-organic disease of the digestive system and the pathophysiology of IBS is still not completely understood. Berberine is used to treat patients with IBS, but little is known regarding to its therapeutic mechanism. This study aimed determine the therapeutic efficacy of berberine on IBS and its underlying mechanisms. The results demonstrate that the therapeutic efficacy of berberine is dose-dependent and maybe associated with inhibition of the intestinal nuclear factor kappa-B signal pathway, the expression of brain derived neurotrophic factor and its receptor TrkB, and the expression of C-kit to reduce intestinal motility and visceral sensitivity.
Citation Yu Z, Cen YX, Wu BH, Wei C, Xiong F, Li DF, Liu TT, Luo MH, Guo LL, Li YX, Wang LS, Wang JY, Yao J. Berberine prevents stress-induced gut inflammation, visceral hypersensitivity and reduces intestinal motility in rats. World J Gastroenterol 2019; 25(29): 3956-3971
2019-02-27 01:31
Peer-Review Started
2019-02-27 07:09
To Make the First Decision
2019-04-11 08:16
Return for Revision
2019-04-12 06:55
2019-06-26 14:24
Second Decision
2019-07-05 10:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-05 23:52
Articles in Press
2019-07-05 23:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-05 08:13
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 03699937, 00503345, and 03000422
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor Yu-Jie Ma
Responsible Science Editor Ze-Mao Gong
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-25-3956.pdf
Full Article (Word) WJG-25-3956.docx
Manuscript File 46893-Review.docx
Answering Reviewers 46893-Answering reviewers.pdf
Audio Core Tip 46893-Audio core tip.mp3
Biostatistics Review Certificate 46893-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 46893-Conflict-of-interest statement.pdf
Copyright License Agreement 46893-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 46893-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 46893-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 46893-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 46893-Language certificate.pdf
Peer-review Report 46893-Peer-review(s).pdf
Scientific Misconduct Check 46893-Scientific misconduct check.pdf
Scientific Editor Work List 46893-Scientific editor work list.pdf