Publication Name	World Journal of Gastroenterology
Manuscript ID	46893
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Berberine prevents stress-induced gut inflammation, visceral hypersensitivity and reduces intestinal motility in rats
Manuscript Source	Unsolicited Manuscript
All Author List	Zhi-Chao Yu, Yong-Xin Cen, Ben-Hua Wu, Cheng Wei, Feng Xiong, De-Feng Li, Ting-Ting Liu, Ming-Han Luo, Li-Liangzi Guo, Ying-Xue Li, Li-Sheng Wang, Jian-Yao Wang and Jun Yao
Funding Agency and Grant Number	Funding Agency Grant Number the National Natural Science Foundation of China 81800489 Three engineering training funds in Shenzhen SYLY201718 Technical Research and Development Project of Shenzhen JCYJ20170307100538697 Technical Research and Development Project of Shenzhen JCYJ20160429174927286 Technical Research and Development Project of Shenzhen JCYJ20170307100911479
Corresponding Author	Jun Yao, MD, PhD, Doctor, Department of Gastroenterology, Jinan University of Second Clinical Medical Sciences, Shenzhen Municipal People’s Hospital, 1017 East Gate Road, Shenzhen 518020, Guangdong Province, China. yj_1108@126.com
Key Words	Irritable bowel syndrome; Visceral hypersensitivity; Berberine; Rifampicin; Nuclear factor kappa-B; Brain-derived neurotrophic factor
Core Tip	Irritable bowel syndrome (IBS) is a common chronic non-organic disease of the digestive system and the pathophysiology of IBS is still not completely understood. Berberine is used to treat patients with IBS, but little is known regarding to its therapeutic mechanism. This study aimed determine the therapeutic efficacy of berberine on IBS and its underlying mechanisms. The results demonstrate that the therapeutic efficacy of berberine is dose-dependent and maybe associated with inhibition of the intestinal nuclear factor kappa-B signal pathway, the expression of brain derived neurotrophic factor and its receptor TrkB, and the expression of C-kit to reduce intestinal motility and visceral sensitivity.
Citation	Yu Z, Cen YX, Wu BH, Wei C, Xiong F, Li DF, Liu TT, Luo MH, Guo LL, Li YX, Wang LS, Wang JY, Yao J. Berberine prevents stress-induced gut inflammation, visceral hypersensitivity and reduces intestinal motility in rats. World J Gastroenterol 2019; 25(29): 3956-3971

Received	2019-02-27 01:31
Peer-Review Started	2019-02-27 07:09
To Make the First Decision	2019-04-11 08:16
Return for Revision	2019-04-12 06:55
Revised	2019-06-26 14:24
Second Decision	2019-07-05 10:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-07-05 23:52
Articles in Press	2019-07-05 23:52
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-08-05 08:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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