Publication Name	World Journal of Gastroenterology
Manuscript ID	47045
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Review
Article Title	Mechanisms of hepatocellular carcinoma progression
Manuscript Source	Invited Manuscript
All Author List	Olorunseun O Ogunwobi, Trisheena Harricharran, Jeannette Huaman, Anna Galuza, Oluwatoyin Odumuwagun, Yin Tan, Grace Ma and Minhhuyen T Nguyen
Funding Agency and Grant Number
Corresponding Author	Olorunseun O Ogunwobi, MBBS, MSc, PhD, Associate Professor, Director, Department of Biological Sciences, Hunter College of the City University of New York, 695 Park Ave, New York, NY 10065, United States. ogunwobi@genectr.hunter.cuny.edu
Key Words	Hepatocellular carcinoma; Viral/non-viral hepatitis; Alcohol consumption; Epithelial-mesenchymal transition; Tumor-stromal interactions; Tumor microenvironment; Cancer stem cells; Circulating tumor cells; Immunomodulation; Neural regulation
Core Tip	The overall prognosis for hepatocellular carcinoma patients remains poor as there has only been minimal improvement over the past 15 years. Details of the mechanisms of hepatocellular carcinoma progression remain unclear. This review discusses a summary of both well-established and newly proposed mechanisms of hepatocellular carcinoma progression. A better understanding of these mechanisms is critical to the development of novel and more effective therapeutic strategies likely to improve hepatocellular carcinoma patient outcomes.
Citation	Ogunwobi OO, Harricharran T, Huaman J, Galuza A, Odumuwagun O, Tan Y, Ma GX, Nguyen MT. Mechanisms of hepatocellular carcinoma progression. World J Gastroenterol 2019; 25(19): 2279-2293

Received	2019-03-08 01:47
Peer-Review Started	2019-03-08 07:16
To Make the First Decision	2019-03-20 06:34
Return for Revision	2019-03-20 08:25
Revised	2019-03-27 15:11
Second Decision	2019-04-04 08:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-04-10 23:50
Articles in Press	2019-04-10 23:50
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-04-21 15:28
Typeset the Manuscript	2019-05-16 00:36

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com