Publication Name	World Journal of Stem Cells
Manuscript ID	47129
Country	Egypt

Category	Cell Biology
Manuscript Type	Basic Study
Article Title	Early therapeutic effect of platelet rich fibrin combined with allogenic bone marrow-derived stem cells on rats' critical sized mandibular defects
Manuscript Source	Invited Manuscript
All Author List	Muhammad A Awadeen, Fouad A Al-Belasy, Laila E Amin, Mohamad E Helal and Mohammed E Grawish
Funding Agency and Grant Number
Corresponding Author	Mohammed E Grawish, MSc, PhD, Professor, Department of Oral Biology, Faculty of Dentistry, Mansoura University, Dakahlia Governorate, Mansoura 740005, Egypt. grawish2005@yahoo.com
Key Words	Platelet rich fibrin membrane; Bone marrow-derived stem cells; Critical-sized mandibular defects; Rats; Histological and immunohistochemical staining;
Core Tip	Our findings derived from rat models for treating the critical sized mandibular bone defects with platelet rich fibrin (PRF) membranes seeded with allogeneic bone marrow-derived stem cells (BMSCs) confirmed the in-vivo anti-inflammatory effects of allogenic BMSCs and indicated that they have beneficial syngeneic effects to the PRF membranes in promoting and accelerating the healing of critically sized mandibular defects. The routine and special histological and immunohistochemical staining demonstrates for the first time that experimentally treated critically sized mandibular defects with the combination therapy of PRF membranes and BMSCs increased the amount and the rate of the newly formed bone and decreased the amount of granulation tissue with the reduction in the number of the inflammatory cell infiltrates.
Citation	Awadeen MA, Al-Belasy FA, Ameen LE, Helal ME, Grawish ME. Early therapeutic effect of platelet rich fibrin combined with allogenic bone marrow-derived stem cells on rats' critical sized mandibular defects. World J Stem Cells 2020; 12(1): 55-69

Received	2019-03-07 01:36
Peer-Review Started	2019-03-08 03:41
To Make the First Decision	2019-04-16 07:41
Return for Revision	2019-05-10 00:18
Revised	2019-05-13 08:22
Second Decision	2019-09-06 10:03
Accepted by Journal Editor-in-Chief	2019-09-06 21:02
Accepted by Company Editor-in-Chief	2019-12-02 19:54
Articles in Press	2019-12-02 19:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-09 06:54

ISSN	1948-0210 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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