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Publication Name World Journal of Stem Cells
Manuscript ID 47129
Country of Manuscript Source Egypt
Specialty Cell Biology
Manuscript Type Basic Study
Article Title Early therapeutic effect of platelet rich fibrin combined with allogenic bone marrow-derived stem cells on rats' critical sized mandibular defects
Manuscript Source Invited Manuscript
All Author List Muhammad A Awadeen, Fouad A Al-Belasy, Laila E Amin, Mohamed E Helal and Mohammed E Grawish
Funding Agency and Grant Number
Corresponding author Mohammed E Grawish, MSc, PhD, Professor, Department of Oral Biology, Faculty of Dentistry, Mansoura University, Dakahlia Governorate, Mansoura 740005, Egypt. grawish2005@yahoo.com
Keywords Platelet rich fibrin membrane; Bone marrow-derived stem cells; Critical-sized mandibular defects; Rats; Histological and immunohistochemical staining;
Core Tip Our findings derived from rat models for treating the critical sized mandibular bone defects with platelet rich fibrin (PRF) membranes seeded with allogeneic bone marrow-derived stem cells (BMSCs) confirmed the in-vivo anti-inflammatory effects of allogenic BMSCs and indicated that they have beneficial syngeneic effects to the PRF membranes in promoting and accelerating the healing of critically sized mandibular defects. The routine and special histological and immunohistochemical staining demonstrates for the first time that experimentally treated critically sized mandibular defects with the combination therapy of PRF membranes and BMSCs increased the amount and the rate of the newly formed bone and decreased the amount of granulation tissue with the reduction in the number of the inflammatory cell infiltrates.
Citation Awadeen MA, Al-Belasy FA, Ameen LE, Helal ME, Grawish ME. Early therapeutic effect of platelet rich fibrin combined with allogenic bone marrow-derived stem cells on rats' critical sized mandibular defects. World J Stem Cells 2019; In press
Received
2019-03-07 01:36
Peer-Review Started
2019-03-08 03:41
To Make the First Decision
2019-04-16 07:41
Return for Revision
2019-05-10 00:18
Revised
2019-05-13 08:22
Second Decision
2019-09-06 10:03
Accepted by Journal Editor-in-Chief
2019-09-06 21:02
Accepted by Company Editor-in-Chief
2019-12-02 19:54
Articles in Press
2019-12-02 19:54
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-12-09 06:54
ISSN 1948-0210 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019 Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jin-Lei Wang
Reviewer Code 02446319, 02567328, and 00504800
Editorial Director Ya-Juan Ma
Journal Chief Editor Shengwen Calvin Li
Company Chief Editor Li Ma
Language Editor
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 47129-Review.docx
Answering Reviewers 47129-Answering reviewers.pdf
Audio Core Tip 47129-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47129-Conflict-of-interest statement.pdf
Copyright License Agreement 47129-Copyright license agreement.pdf
Institutional Animal Care and Use Committee Approval Form or Document 47129-Institutional animal care and use committee statement.pdf
Non-Native Speakers of English Editing Certificate 47129-Language certificate.pdf
Peer-review Report 47129-Peer-review(s).pdf
Journal Editor-in-Chief Review Report 47129-Journal Editor-in-Chief Review Report.pdf
Scientific Misconduct Check 47129-Scientific misconduct check.pdf
Scientific Editor Work List 47129-Scientific editor work list.pdf