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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 47204
Country of Manuscript Source Japan
Specialty Gastroenterology and Hepatology
Manuscript type Observational Study
Article Title Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients
Manuscript Source Unsolicited Manuscript
All Author List Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Naotaka Shimozato, Kosuke Kaji, Yuki Tsuji, Keisuke Nakanishi, Ryuichi Noguchi, Yukihisa Fujinaga, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Kei Moriya, Takemi Akahane and Hitoshi Yoshiji
Funding Agency and Grant Number
Correspondence To Hiroaki Takaya, MD, PhD, Assistant Professor, Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 6348522, Japan. htky@naramed-u.ac.jp
Keywords Acylcarnitine; Acetylcarnitine; Biomarker; Hepatocellular carcinoma; Angiogenesis; Carnitine palmitoyltransferase 1
Core Tip There is an urgent clinical need for the early diagnosis of hepatocellular carcinoma (HCC) in cirrhotic patients to improve prognosis. A recent study reported that a high level of acylcarnitine may be a useful biomarker for the early diagnosis of HCC in steatohepatitis (SH) patients. However, the level of acylcarnitine was significantly lower in non-SH patients with HCC than in those without HCC. Multivariate analysis showed that a low level of acylcarnitine was the only independent early diagnostic biomarker for non-SH HCC. Thus, the fatty acid metabolic pathways in SH HCC and non-SH HCC patients may be different.
Citation Takaya H, Namisaki T, Kitade M, Shimozato N, Kaji K, Tsuji Y, Nakanishi K, Noguchi R, Fujinaga Y, Sawada Y, Saikawa S, Sato S, Kawaratani H, Moriya K, Akahane T, Yoshiji H. Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients. World J Gastrointest Oncol 2019; In press
Received
2019-03-21 06:03
Peer-Review Started
2019-03-26 00:14
To Make the First Decision
2019-08-01 00:15
Return for Revision
2019-08-27 07:24
Revised
2019-09-03 08:47
Second Decision
2019-09-10 08:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-10 22:07
Articles in Press
2019-09-10 22:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 03009708, and 03647890
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 47204-Review.docx
Answering Reviewers 47204-Answering reviewers.pdf
Audio Core Tip 47204-Audio core tip.m4a
Biostatistics Review Certificate 47204-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47204-Conflict-of-interest statement.pdf
Copyright License Agreement 47204-Copyright license agreement.pdf
Signed Informed Consent Form(s) or Document(s) 47204-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47204-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47204-Language certificate.pdf
Peer-review Report 47204-Peer-review(s).pdf
Scientific Misconduct Check 47204-Scientific misconduct check.pdf
Scientific Editor Work List 47204-Scientific editor work list.pdf