Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	47204
Country	Japan

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients
Manuscript Source	Unsolicited Manuscript
All Author List	Hiroaki Takaya, Tadashi Namisaki, Mitsuteru Kitade, Naotaka Shimozato, Kosuke Kaji, Yuki Tsuji, Keisuke Nakanishi, Ryuichi Noguchi, Yukihisa Fujinaga, Yasuhiko Sawada, Soichiro Saikawa, Shinya Sato, Hideto Kawaratani, Kei Moriya, Takemi Akahane and Hitoshi Yoshiji
Funding Agency and Grant Number
Corresponding Author	Hiroaki Takaya, MD, PhD, Assistant Professor, Third Department of Internal Medicine, Nara Medical University, 840 Shijo-cho, Kashihara 6348522, Japan. htky@naramed-u.ac.jp
Key Words	Acylcarnitine; Acetylcarnitine; Biomarker; Hepatocellular carcinoma; Angiogenesis; Carnitine palmitoyltransferase 1
Core Tip	There is an urgent clinical need for the early diagnosis of hepatocellular carcinoma (HCC) in cirrhotic patients to improve prognosis. A recent study reported that a high level of acylcarnitine may be a useful biomarker for the early diagnosis of HCC in steatohepatitis (SH) patients. However, the level of acylcarnitine was significantly lower in non-SH patients with HCC than in those without HCC. Multivariate analysis showed that a low level of acylcarnitine was the only independent early diagnostic biomarker for non-SH HCC. Thus, the fatty acid metabolic pathways in SH HCC and non-SH HCC patients may be different.
Citation	Takaya H, Namisaki T, Kitade M, Shimozato N, Kaji K, Tsuji Y, Nakanishi K, Noguchi R, Fujinaga Y, Sawada Y, Saikawa S, Sato S, Kawaratani H, Moriya K, Akahane T, Yoshiji H. Acylcarnitine: Useful biomarker for early diagnosis of hepatocellular carcinoma in non-steatohepatitis patients. World J Gastrointest Oncol 2019; 11(10): 887-897

Received	2019-03-21 06:03
Peer-Review Started	2019-03-26 00:14
To Make the First Decision	2019-08-01 00:15
Return for Revision	2019-08-27 07:24
Revised	2019-09-03 08:47
Second Decision	2019-09-10 08:36
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-10 22:07
Articles in Press	2019-09-10 22:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-12 11:08

ISSN	1948-5204 (online)
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