Publication Name	World Journal of Gastrointestinal Endoscopy
Manuscript ID	47248
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Observational Study
Article Title	Endoscopic ultrasound-through-the-needle biopsy in pancreatic cystic lesions: A large single center experience
Manuscript Source	Invited Manuscript
All Author List	Rintaro Hashimoto, John G Lee, Kenneth J Chang, Nabil El Hage Chehade and Jason B Samarasena
Funding Agency and Grant Number
Corresponding Author	Rintaro Hashimoto, MD, PhD, Doctor, H. H. Chao Comprehensive Digestive Disease Center, Division of Gastroenterology and Hepatology, Department of Medicine, University of California, Irvine, 333 City Blvd West, Suite 400, Orange, CA 92868, United States. rintaroh@uci.edu
Key Words	Pancreatic cyst lesion; Endoscopic ultrasound; Endoscopic ultrasound-guided fine needle aspiration; Cyst fluid; Biopsy;
Core Tip	Establishing a diagnosis of pancreatic cystic lesions (PCLs) preoperatively still remains a challenge. Endoscopic ultrasound (EUS)-through-the-needle biopsy (EUS-TTNB) using microforceps was recently used to make a definitive diagnosis of PCLs. The aim of this study was to assess the safety and efficacy of EUS-TTNB compared with EUS-fine-needle aspiration (FNA), and feasibility of intrapapillary mucinous neoplasm (IPMN) subtyping using EUS-TTNB specimen. Fifty-six patients underwent EUS-TTNB. The rates of technical success, clinical success, and adverse events were 100%, 80.4% and 3.6%, respectively. The clinical success rate was higher in EUS-TTNB (80.4%) than in EUS-FNA (15%). IPMN subtyping was successful in 71.9% (23/32) in patients with IPMN.
Citation	Hashimoto R, Lee JG, Chang KJ, El Hage Chehade N, Samarasena JB. Endoscopic ultrasound-through-the-needle biopsy in pancreatic cystic lesions: A large single center experience. World J Gastrointest Endosc 2019; In press

Received	2019-03-18 06:11
Peer-Review Started	2019-03-18 12:17
To Make the First Decision	2019-05-16 23:50
Return for Revision	2019-05-17 00:21
Revised	2019-09-25 17:51
Second Decision	2019-10-17 06:32
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-10-18 22:07
Articles in Press	2019-10-18 22:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-10-31 05:21

ISSN	1948-5190 (online)
Open Access	This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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