| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Cohort Study |
| Article Title |
Prognostic value of preoperative carcinoembryonic antigen/tumor size in rectal cancer
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Du Cai, Zeng-Hong Huang, Hui-Chuan Yu, Xiao-Lin Wang, Liang-Liang Bai, Guan-Nan Tang, Shao-Yong Peng, Ying-Jie Li, Meijin Huang, Guang-Wen Cao, Jian-Ping Wang and Yan-Xin Luo |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 81472257, YL; No. 81502022, XW |
| National Basic Research Program of China (973 Program) |
No. 2015CB554001, JW |
| Natural Science Fund for Distinguished Young Scholars of Guangdong Province |
No. 2016A030306002, YL |
| Tip-top Scientific and Technical Innovative Youth Talents of Guangdong special support program |
No. 2015TQ01R454, YL |
| Natural Science Foundation of Guangdong Province |
No. 2016A030310222, HY |
| Science and Technology Program of Guangzhou |
No. 201506010099, YL; No. 2014Y2-00160, JW |
| Fundamental Research Funds for the Central Universities (Sun Yat-sen University) |
No. 2015ykzd10, YL; No. 16ykpy35, XW |
|
| Corresponding Author |
Yan-Xin Luo, MA, MD, PhD, Associate Professor, Chief Doctor, Doctor, Surgical Oncologist, Department of Colorectal Surgery, Guangdong Institute of Gastroenterology, Guangdong Provincial Key Laboratory of Colorectal and Pelvic Floor Disease, The Sixth Affiliated Hospital, Sun Yat-sen University, 26 Yuancun Erheng Road, Guangzhou 510655, Guangdong Province, China. luoyx25@mail.sysu.edu.cn |
| Key Words |
Carcinoembryonic antigen; Carcinoembryonic antigen/tumor size; Rectal cancer; Prognosis; Survival analysis; |
| Core Tip |
This is a retrospective study that sought to evaluate the prognostic value of carcinoembryonic antigen (CEA)/tumor size in rectal cancer, which may better reflect the tumor malignancy. Maximally selected rank statistics identified an optimal cutoff point of 2.429 ng/mL per cm for CEA/tumor size. Kaplan-Meier curves showed a significant reduction in the 5-year overall survival and disease free survival in the high CEA/tumor size group. Univariate and multivariate analyses identified CEA/tumor size as an independent prognostic factor for stage I to III rectal cancer. |
| Citation |
Cai D, Huang ZH, Yu HC, Wang XL, Bai LL, Tang GN, Peng SY, Li YJ, Huang MJ, Cao GW, Wang JP, Luo YX. Prognostic value of preoperative carcinoembryonic antigen/tumor size in rectal cancer. World J Gastroenterol 2019; 25(33): 4945-4958 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
