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Publication Name World Journal of Gastroenterology
Manuscript ID 47352
Country of Manuscript Source Canada
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Study
Article Title Histologic features and genomic alterations of primary colorectal adenocarcinoma predict the growth patterns of liver metastasis
Manuscript Source Unsolicited Manuscript
All Author List Jing-Bo Wu, Ali Lopez Sarmiento, Pierre-Olivier Fiset, Anthoula Lazaris, Stephanie Petrillo, Peter Metrakos and Zu-Hua Gao
Funding Agency and Grant Number
Funding Agency Grant Number
the Human Resources Development Program for the Outstanding Talents in the Fifth People’s Hospital of Shanghai, Fudan University 2017WYRCJY09
the Key Medical Speciality of The Fifth People’s Hospital of Shanghai, Fudan University 2017WY202K08
Correspondence To Zu-Hua Gao, FRCPC, MD, PhD, Professor, Department of Pathology, McGill University and the Research Institute of McGill University Health Center, Room E04.1820, 1001 Decarie Boulevard, Montreal H4A 3J1, Quebec, Canada. zu-hua.gao@mcgill.ca
Keywords Colorectal carcinoma; Liver metastasis; Histologic growth pattern; Clinicopathological characteristics; Whole exome sequencing
Core Tip Different histological growth patterns (HGPs) of colorectal carcinoma (CRC) liver metastasis were associated with patient’s prognosis and response to antiangiogenic therapy. The aim of our study was to assess whether certain clinicopathological and genomic features of primary CRC could predict the HGPs of liver metastasis. We found that the HGPs, tumor budding score (TBS), Crohn’s disease-like response (CDR) of primary CRC and the presence of specific genetic mutations such as PIK3CA could be used to predict the histological growth patterns of liver metastasis, response to therapy and patient’s prognosis.
Citation Wu JB, Sarmiento AL, Fiset PO, Lazaris A, Petrillo S, Metrakos P, Gao ZH. Histologic features and genomic alterations of primary colorectal adenocarcinoma predict the growth patterns of liver metastasis. World J Gastroenterol 2019; In press
Received
2019-03-18 06:49
Peer-Review Started
2019-03-19 00:32
To Make the First Decision
2019-05-14 02:13
Return for Revision
2019-05-14 03:57
Revised
2019-06-05 00:41
Second Decision
2019-06-05 10:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-08 15:03
Articles in Press
2019-06-08 15:03
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-06-13 01:03
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 03476659, and 00914743
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 47352-Review_Edited.docx
Answering Reviewers 47352-Answering reviewers.pdf
Audio Core Tip 47352-Audio core tip.mp3
Biostatistics Review Certificate 47352-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47352-Conflict-of-interest statement.pdf
Copyright License Agreement 47352-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47352-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 47352-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47352-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47352-Language certificate.pdf
Peer-review Report 47352-Peer-review(s).pdf
Scientific Misconduct Check 47352-Google-MA RY-1.png
Scientific Misconduct Check 47352-Google-MA RY-2.png
Scientific Misconduct Check 47352-Scientific misconduct check.pdf
Scientific Editor Work List 47352-Scientific editor work list.pdf