Publication Name	World Journal of Gastroenterology
Manuscript ID	47352
Country	Canada

Category	Gastroenterology & Hepatology
Manuscript Type	Retrospective Study
Article Title	Histologic features and genomic alterations of primary colorectal adenocarcinoma predict the growth patterns of liver metastasis
Manuscript Source	Unsolicited Manuscript
All Author List	Jing-Bo Wu, Ali Lopez Sarmiento, Pierre-Olivier Fiset, Anthoula Lazaris, Stephanie Petrillo, Peter Metrakos and Zu-Hua Gao
Funding Agency and Grant Number	Funding Agency Grant Number the Human Resources Development Program for the Outstanding Talents in the Fifth People’s Hospital of Shanghai, Fudan University 2017WYRCJY09 the Key Medical Speciality of The Fifth People’s Hospital of Shanghai, Fudan University 2017WY202K08
Corresponding Author	Zu-Hua Gao, FRCPC, MD, PhD, Professor, Department of Pathology, McGill University and the Research Institute of McGill University Health Center, Room E04.1820, 1001 Decarie Boulevard, Montreal H4A 3J1, Quebec, Canada. zu-hua.gao@mcgill.ca
Key Words	Colorectal carcinoma; Liver metastasis; Histologic growth pattern; Clinicopathological characteristics; Whole exome sequencing
Core Tip	Different histological growth patterns (HGPs) of colorectal carcinoma (CRC) liver metastasis were associated with patient’s prognosis and response to antiangiogenic therapy. The aim of our study was to assess whether certain clinicopathological and genomic features of primary CRC could predict the HGPs of liver metastasis. We found that the HGPs, tumor budding score (TBS), Crohn’s disease-like response (CDR) of primary CRC and the presence of specific genetic mutations such as PIK3CA could be used to predict the histological growth patterns of liver metastasis, response to therapy and patient’s prognosis.
Citation	Wu JB, Sarmiento AL, Fiset PO, Lazaris A, Petrillo S, Metrakos P, Gao ZH. Histologic features and genomic alterations of primary colorectal adenocarcinoma predict the growth patterns of liver metastasis. World J Gastroenterol 2019; 25(26): 3408-3425

Received	2019-03-18 06:49
Peer-Review Started	2019-03-19 00:32
To Make the First Decision	2019-05-14 02:13
Return for Revision	2019-05-14 03:57
Revised	2019-06-05 00:41
Second Decision	2019-06-05 10:35
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-06-08 15:03
Articles in Press	2019-06-08 15:03
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-06-13 01:03
Typeset the Manuscript	2019-07-13 11:39

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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