Publication Name	World Journal of Gastroenterology
Manuscript ID	47404
Country	United States

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review
Manuscript Source	Invited Manuscript
All Author List	Pamela A Norton and Anand S Mehta
Funding Agency and Grant Number
Corresponding Author	Pamela A Norton, PhD, Associate Professor, Department of Microbiology and Immunology, Drexel University College of Medicine, 245 N. 15th Street, Philadelphia, PA 19102, United States. pamela.norton@drexelmed.edu
Key Words	Liver cancer; N-linked glycosylation; Fucose; Guanosine diphosphate fucose; Hepatocellular carcinoma
Core Tip	The increased level of core fucosylated N-linked glycoproteins detected in some patients with hepatocellular carcinoma may occur via several potential molecular mechanisms. We report that the genes GMDS and TSTA3, which are associated with the de novo synthesis of the fucose donor species, guanosine diphosphate fucose, can be amplified in some hepatocellular carcinoma patients. Amplification seems to be the most common genetic alteration affecting the genes that control the production of core fucosylated proteins.
Citation	Norton PA, Mehta AS. Expression of genes that control core fucosylation in hepatocellular carcinoma: Systematic review. World J Gastroenterol 2019; 25(23): 2947-2960

Received	2019-03-14 03:49
Peer-Review Started	2019-03-14 07:41
To Make the First Decision	2019-04-11 08:23
Return for Revision	2019-04-12 03:12
Revised	2019-04-25 21:19
Second Decision	2019-05-17 09:04
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-18 12:45
Articles in Press	2019-05-18 12:45
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-19 05:46

ISSN	1007-9327 (print) and 2219-2840 (online)
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