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8/21/2019 11:18:23 PM | Browse: 263 | Download: 216
Publication Name World Journal of Clinical Oncology
Manuscript ID 47564
Country/Territory Singapore
Category Oncology
Manuscript Type Editorial
Article Title Novel mechanism of drug resistance to proteasome inhibitors in multiple myeloma
Manuscript Source Invited Manuscript
All Author List Jianbiao Zhou and Wee-Joo Chng
Funding Agency and Grant Number
Corresponding Author Jianbiao Zhou, MD, PhD, Senior Scientist, Cancer Science Institute of Singapore, National University of Singapore, Centre for Translational Medicine, 28 Medical Drive, Singapore 117456, Singapore. csizjb@nus.edu.sg
Key Words Multiple myeloma; Proteasome inhibitor; Bortezomib; Proteasome β5-subunit; Drug resistance; Clonal evolution
Core Tip Multiple myeloma (MM) is the second common hematologic malignancy. An array of new treatments has been approved over the last decade. Hence, the survival of MM patients has improved steadily. Among these new drugs, the first-in-class proteasome inhibitor bortezomib has been revolutionary for targeted therapy. Now bortezomib is the backbone for treating MM. However, emerging drug resistance poses a major challenge for clinicians to use proteasome inhibitors. In this editorial, we discuss proteasome β5-subunit mutations as a novel resistant mechanism to bortezomib and its implication in tracking clonal evolution and suggest potential strategies to overcome drug resistance.
Citation Zhou J, Chng WJ. Novel mechanism of drug resistance to proteasome inhibitors in multiple myeloma. World J Clin Oncol 2019; 10(9): 303-306
Received
2019-03-19 01:34
Peer-Review Started
2019-03-19 14:59
To Make the First Decision
2019-08-06 06:37
Return for Revision
2019-08-08 08:04
Revised
2019-08-14 00:40
Second Decision
2019-08-21 08:44
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-21 23:18
Articles in Press
2019-08-21 23:18
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-08-28 13:42
Typeset the Manuscript
2019-09-04 01:18
ISSN 2218-4333 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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