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7/5/2019 11:42:18 PM | Browse: 204 | Download: 75
Publication Name World Journal of Gastroenterology
Manuscript ID 47581
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript Type Basic Study
Article Title Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway
Manuscript Source Unsolicited Manuscript
All Author List Gao-Liang Zou, Shi Zuo, Shuang Lu, Rui-Han Hu, Yin-Ying Lu, Jing Yang, Kai-Sheng Deng, Ye-Ting Wu, Mao Mu, Juan-Juan Zhu, Jing-Zhang Zeng, Bao-Fang Zhang, Xian Wu, Xue-Ke Zhao and Hai-Yang Li
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81560104
National Natural Science Foundation of China 81860115
Corresponding author Xue-Ke Zhao, MD, PhD, Adjunct Professor, Department of Infectious Diseases, Affiliated Hospital of Guizhou Medical University, No. 28, Guiyi Road, Guiyang 550004, Guizhou Province, China. zhaoxueke1@163.com
Keywords Liver fibrosis; Bone morphogenetic protein; Transforming growth factor; Hepatic stellate cells; ;
Core Tip Liver fibrosis is the repair response of the liver to chronic injury. Its long-term persistence can eventually progress into cirrhosis or even liver cancer. Many cytokines and signaling pathways participate in the development and progression of liver fibrosis. The transforming growth factor-beta (TGF-β) superfamily member bone morphogenetic protein 7 (BMP7) is reported to have anti-fibrosis functions. This study observed changes in the dynamic expression of BMP7 during liver fibrosis, explored the relationship between BMP7 and TGF-β1, and further investigated the possible mechanism underlying the anti-liver fibrosis function of exogenous BMP7 using in vivo and in vitro experiments. This study demonstrated the prospect of exogenous BMP7 application as a potential anti-liver fibrosis drug.
Citation Zou GL, Zuo S, Lu S, Hu RH, Lu YY, Yang J, Deng KS, Wu YT, Mu M, Zhu JJ, Zeng JZ, Zhang BF, Wu X, Zhao XK, Li HY. Bone morphogenetic protein-7 represses hepatic stellate cell activation and liver fibrosis via regulation of TGF-β/Smad signaling pathway. World J Gastroenterol 2019; 25(30): 4222-4234
2019-04-16 00:26
Peer-Review Started
2019-04-16 00:59
To Make the First Decision
2019-06-10 07:54
Return for Revision
2019-06-11 01:18
2019-06-25 07:26
Second Decision
2019-07-05 10:33
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-05 23:42
Articles in Press
2019-07-05 23:42
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-15 08:43
Typeset the Manuscript
2019-08-14 07:08
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 01435993, and 02860849
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor Yan-Liang Zhang
Responsible Electronic Editor Yan-Liang Zhang
Responsible Science Editor Ya-Juan Ma
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-25-4222.pdf
Full Article (Word) WJG-25-4222.docx
Manuscript File 47581-Review_Edited.docx
Answering Reviewers 47581-Answering reviewers.pdf
Audio Core Tip 47581-Audio core tip.mp3
Biostatistics Review Certificate 47581-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47581-Conflict-of-interest statement.pdf
Copyright License Agreement 47581-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47581-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 47581-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 47581-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47581-Language certificate.pdf
Peer-review Report 47581-Peer-review(s).pdf
Scientific Misconduct Check 47581-Google-MA RY-2.png
Scientific Misconduct Check 47581-Scientific misconduct check.pdf
Scientific Editor Work List 47581-Scientific editor work list.pdf