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Publication Name World Journal of Gastroenterology
Manuscript ID 47640
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Cohort Study
Article Title Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients
Manuscript Source Unsolicited Manuscript
All Author List Wen-Ying Xia, Li Gao, Er-Hei Dai, Dan Chen, Er-Fu Xie, Li Yang, Shi-Chang Zhang, Bing-Feng Zhang, Jian Xu and Shi-Yang Pan
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81672100
National Natural Science Foundation of China 81371894
Key Laboratory for Laboratory Medicine of Jiangsu Province of China ZDXKB2016005
Jiangsu Provincial Commission of Health and Family Planning H201609
Correspondence To Shi-Yang Pan, MD, Professor, Department of Laboratory Medicine, the First Affiliated Hospital of Nanjing Medical University, Guangzhou Road No. 300, Nanjing 210029, Jiangsu Province, China. sypan@njmu.edu.cn
Keywords Liquid biopsy; plasma DNA; Hepatitis B; Alanine aminotransferase; Duplex real-time quantitative polymerase chain reaction
Core Tip Our study quantified cell free DNA combined with other serum biomarker as a liquid biopsy-based method to assess liver injury in hepatitis B patients. A cohort of 663 subjects including 313 hepatitis B patients and 350 healthy controls were enrolled. The ultrasound-guided liver biopsies followed by histopathological assessments were performed for the 263 chronic hepatitis B patients to determine the degree of liver injury. Cell-free DNA was quantified using a novel duplex real-time polymerase chain reaction assay. Our results demonstrated that the combination of plasma DNA, serum alanine aminotransferase and bilirubin could be a candidate liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients.
Citation Xia WY, Gao L, Dai EH, Chen D, Xie EF, Yang L, Zhang SC, Zhang BF, Xu J, Pan SY. Liquid biopsy for non-invasive assessment of liver injury in hepatitis B patients. World J Gastroenterol 2019; In press
Received
2019-03-26 02:20
Peer-Review Started
2019-03-26 04:55
To Make the First Decision
2019-05-27 00:35
Return for Revision
2019-05-31 01:50
Revised
2019-06-13 15:31
Second Decision
2019-07-05 10:26
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-05 23:48
Articles in Press
2019-07-05 23:48
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-15 03:35
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 00036801, 00646291, and 00630200
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 47640-Review_Edited.doc
Answering Reviewers 47640-Answering reviewers.pdf
Audio Core Tip 47640-Audio core tip.mp3
Biostatistics Review Certificate 47640-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 47640-Conflict-of-interest statement.pdf
Copyright License Agreement 47640-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 47640-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 47640-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 47640-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 47640-Language certificate.pdf
Peer-review Report 47640-Peer-review(s).pdf
Scientific Misconduct Check 47640-Scientific misconduct check.pdf
Scientific Editor Work List 47640-Scientific editor work list.pdf