Publication Name	World Journal of Clinical Oncology
Manuscript ID	47669
Country	Uruguay

Category	Oncology
Manuscript Type	Systematic Reviews
Article Title	Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review
Manuscript Source	Invited Manuscript
All Author List	Rogelio González-González, Sandra López-Verdín, Jesús Lavalle-Carrasco, Nelly Molina-Frechero, Mario Isiordia-Espinoza, Ramón G Carreón-Burciaga and Ronell Bologna-Molina
Funding Agency and Grant Number
Corresponding Author	Ronell Bologna-Molina, DDS, MSc, PhD, Postdoc, Professor, Research Scientist, Senior Scientist, Molecular Pathology, School of Dentistry, Universidad de la República de Uruguay (UDELAR), Las Heras 1925, Montevideo 11600, Montevideo, Uruguay. ronellbologna@odon.edu.uy
Key Words	Ameloblastoma; B-raf proto-oncogene serine/threonine kinase; B-raf proto-oncogene serine/threonine kinase V600E; Additional mutations; Targeted therapies;
Core Tip	Ameloblastoma is a common neoplasia that is developed from odontogenic epithelium. It is an aggressive and recurrent tumor that can present metastases or malignant transformation. This neoplasia is characterized by presenting different clinical and histological varieties as well as several mutations related to its behavior. Nowadays, there are several studies focused on targeted therapies against the mutations of this tumor, one of the most frequent ones being B-raf proto-oncogene serine/threonine kinase (BRAF) V600E, the treatment of which has been associated with good response. These targeted therapies are suitable for resistant tumors. This study focused on BRAF V600E mutations and its additional mutations and targeted therapies.
Citation	González-González R, López-Verdín S, Lavalle-Carrasco J, Molina-Frechero N, Isiordia-Espinoza M, Carreón-Burciaga RG, Bologna-Molina R. Current concepts in ameloblastoma-targeted therapies in B-raf proto-oncogene serine/threonine kinase V600E mutation: Systematic review. World J Clin Oncol 2020; 11(1): 31-42

Received	2019-03-23 06:36
Peer-Review Started	2019-03-26 00:40
To Make the First Decision	2019-09-11 00:10
Return for Revision	2019-09-11 09:17
Revised	2019-10-23 19:45
Second Decision	2019-11-05 07:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-06 19:41
Articles in Press	2019-11-06 19:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-18 02:53

ISSN	2218-4333 (online)
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