Publication Name	World Journal of Gastroenterology
Manuscript ID	47672
Country	Spain

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease
Manuscript Source	Invited Manuscript
All Author List	Jose M Mato, Cristina Alonso, Mazen Noureddin and Shelly C Lu
Funding Agency and Grant Number
Corresponding Author	Jose M Mato, PhD, Director, Professor, CIC bioGUNE, Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (Ciberehd), Technology Park of Bizkaia, Derio 48160, Bizkaia, Spain. director@cicbiogune.es
Key Words	S-adenosylmethionine; Methionine adenosyltransferase; Lipid metabolism; Multiomics; Lipidomics; Nonalcoholic steatohepatitis; One-carbon metabolism; Very low-density lipoproteins; Steatosis; Precision medicine
Core Tip	Nonalcoholic fatty liver disease (NAFLD) is a heterogeneous and complex disease that is imprecisely diagnosed by liver biopsy. The advent of metabolomics has shown that NAFLD progression from simple steatosis to nonalcoholic steatohepatitis (NASH) associates with profound alterations in liver and serum lipidomic signatures that are good indicators of the disease’s development and progression. Lipidomics has also permitted the classification of NAFLD patients into different subtypes corresponding to the main alteration(s) leading, in each case, to the initiation and progression of NASH based on the identification of specific lipid signatures, opening the door to the development of precise NASH treatments.
Citation	Mato JM, Alonso C, Noureddin M, Lu SC. Biomarkers and subtypes of deranged lipid metabolism in non-alcoholic fatty liver disease. World J Gastroenterol 2019; 25(24): 3009-3020

Received	2019-03-22 02:00
Peer-Review Started	2019-03-22 07:27
To Make the First Decision	2019-04-11 08:57
Return for Revision	2019-04-12 02:19
Revised	2019-05-06 17:26
Second Decision	2019-05-17 09:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-05-18 12:43
Articles in Press	2019-05-18 12:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-06-27 08:20

ISSN	1007-9327 (print) and 2219-2840 (online)
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