Publication Name	World Journal of Orthopedics
Manuscript ID	47803
Country	Netherlands

Category	Orthopedics
Manuscript Type	Retrospective Cohort Study
Article Title	Good accuracy of the alpha-defensin lateral flow test for hip periprosthetic joint infection: A pilot study in a retrospective cohort of 52 patients
Manuscript Source	Unsolicited Manuscript
All Author List	Jesse WP Kuiper, Pieter Pander and Stan J Vos
Funding Agency and Grant Number
Corresponding Author	Jesse WP Kuiper, MD, MSc, Doctor, Department of Orthopedic Surgery, Noordwest Ziekenhuisgroep, Wilhelminalaan 12, Alkmaar 1815 JD, Netherlands. jwp.kuiper@gmail.com
Key Words	Periprosthetic; Arthroplasty; Replacement; Hip; Infection; Periprosthetic joint infection
Core Tip	The alpha-defensin lateral flow (ADLF) test is a new diagnostic tool for periprosthetic joint infection (PJI). We evaluated a cohort of 52 patients that underwent aspiration of hip arthroplasty to assess test accuracy. Using Musculoskeletal Infection Society criteria, sensitivity was 100% (CI: 54%-100%) and specificity was 89% (CI: 76%-96%). Using European Bone and Joint Infection Society criteria, sensitivity was lower (71%, CI: 42%-92%) and specificity was higher (97%, CI: 86%-100%), Using 2018 International Consensus Meeting criteria, sensitivity was 91% (62%-100%) and specificity 100% (91%-100%). The results in this cohort are comparable to previous studies.
Citation	Kuiper JWP, Pander P, J Vos SJ. Good accuracy of the alpha-defensin lateral flow test for hip periprosthetic joint infection: A pilot study in a retrospective cohort of 52 patients. World J Orthop 2020; 11(1): 36-46

Received	2019-03-25 05:29
Peer-Review Started	2019-03-26 01:38
To Make the First Decision	2019-06-12 00:37
Return for Revision	2019-06-20 08:58
Revised	2019-10-18 14:39
Second Decision	2019-11-05 02:55
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-11-07 21:04
Articles in Press	2019-11-07 21:04
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-12-24 07:35

ISSN	2218-5836 (online)
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