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Publication Name World Journal of Gastrointestinal Surgery
Manuscript ID 47832
Country of Manuscript Source Italy
Specialty Surgery
Manuscript type Minireviews
Article Title Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma: Review of the literature
Manuscript Source Invited Manuscript
All Author List Fabio Frosio, Federico Mocchegiani, Grazia Conte, Enrico Dalla Bona, Andrea Vecchi, Daniele Nicolini and Marco Vivarelli
Funding Agency and Grant Number
Correspondence To Federico Mocchegiani, MD, Assistant Professor, Unit of Hepato-pancreato-biliary and Transplant Surgery, Department of Experimental and Clinical Medicine, Polytechnic University of Marche, Via Conca 71, Ancona 60126, Italy. federicomocchegiani@hotmail.com
Keywords Hilar cholangiocarcinoma; Klatskin tumor; Neoadjuvant treatement; Radiotherapy; Chemotherapy; Hepatic resection; Liver transplantation
Core Tip Surgery is the only potentially curative treatment for hilar cholangiorcinoma; however, most of the patients are considered not resectable because of the local extent. Neoadjuvant radiochemotherapy is supposed to increase R0 margins rate, or even to allow radical resection for locally advanced tumors, but few studies are available. Moreover, for patients with early stage tumors meeting the Mayo Clinic criteria, neoadjuvant therapy before liver transplantation has produced very good survivals, gaining worldwide acceptance. This is the first review to consider the role of neoadjuvant treatment for hilar cholangiocarcinoma, before resection as well as before liver transplantation.
Citation Frosio F, Mocchegiani F, Conte G, Dalla Bona E, Vecchi A, Nicolini D, Vivarelli M. Neoadjuvant therapy in the treatment of hilar cholangiocarcinoma: Review of the literature. World J Gastrointest Surg 2019; 11(6): 279-286
Received
2019-03-26 00:25
Peer-Review Started
2019-03-28 09:41
To Make the First Decision
2019-05-09 00:21
Return for Revision
2019-05-09 02:21
Revised
2019-05-29 23:39
Second Decision
2019-06-10 02:42
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-06-10 22:07
Articles in Press
2019-06-10 22:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-06-27 01:08
ISSN 1948-9366 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jin-Lei Wang
Reviewer Code 02462725, and 03548113
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor Jie Wang
Responsible Electronic Editor Jie Wang
Responsible Science Editor Ze-Mao Gong
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJGS-11-279.pdf
Full Article (Word) WJGS-11-279.docx
Manuscript File 47832-Review.docx
Answering Reviewers 47832-Answering reviewers.pdf
Audio Core Tip 47832-Audio core tip.wav
Conflict-of-Interest Disclosure Form 47832-Conflict-of-interest statement.pdf
Copyright License Agreement 47832-Copyright license agreement.pdf
Peer-review Report 47832-Peer-review(s).pdf
Scientific Misconduct Check 47832-Scientific misconduct check.pdf
Scientific Editor Work List 47832-Scientific editor work list.pdf