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7/5/2019 11:46:09 PM | Browse: 426 | Download: 454
Publication Name World Journal of Gastroenterology
Manuscript ID 47869
Country/Territory Thailand
Category Gastroenterology & Hepatology
Manuscript Type Basic Study
Article Title Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular patterns
Manuscript Source Unsolicited Manuscript
All Author List Arunya Jiraviriyakul, Worawat Songjang, Pongsathorn Kaewthet, Phachsita Tanawatkitichai, Punyapat Bayan and Sutatip Pongcharoen
Funding Agency and Grant Number
Funding Agency Grant Number
Naresuan University R2559B102
Naresuan University R2562C012
Thailand Research Fund BRG6180010
Corresponding Author Sutatip Pongcharoen, PhD, Associate Professor, Division of Immunology, Department of Medicine, Faculty of Medicine, Naresuan University, Tapho District, Muang, Meaung 65000, Phitsanulok, Thailand. sutatipp@nu.ac.th
Key Words Cholangiocarcinoma; Dendritic cells; Honokiol; Damage-associated molecular patterns; Tumor cell lysates;
Core Tip We constructed dendritic cells (DCs) loaded with cell lysates derived from honokiol-treated cholangiocarcinoma tumour cells, with the aim of eliciting apoptosis in tumour cells and creating a broad array of tumour associated antigents in the form of dead and dying cells. Our data demonstrated that honokiol-treated cholangiocacinoma cells-derived tumour cell lysates could improve the fuctions for effector T lymphocytes in killing of the cancer cells. This suggested that honokiol enhanced the immunogenicity of cholangiocarcinoma antigens with increased effectiveness of DC-based vaccine formulation.
Citation Jiraviriyakul A, Songjang W, Kaewthet P, Tanawatkitichai P, Bayan P, Pongcharoen S. Honokiol-enhanced cytotoxic T lymphocyte activity against cholangiocarcinoma cells mediated by dendritic cells pulsed with damage-associated molecular pattern. World J Gastroenterol 2019; 25(29): 3941-3955
Received
2019-03-29 01:06
Peer-Review Started
2019-03-29 03:29
To Make the First Decision
2019-06-10 08:17
Return for Revision
2019-06-14 02:24
Revised
2019-06-21 09:23
Second Decision
2019-07-05 10:28
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-05 23:46
Articles in Press
2019-07-05 23:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-08-05 08:38
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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