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Publication Name World Journal of Cardiology
Manuscript ID 47924
Country of Manuscript Source United States
Specialty Cardiac and Cardiovascular Systems
Manuscript type Editorial
Article Title Novel lipid-modifying therapies addressing unmet needs in cardiovascular disease
Manuscript Source Invited Manuscript
All Author List Constantine E Kosmas, Andreas Sourlas, Delia Silverio, Peter D Montan and Eliscer Guzman
Funding Agency and Grant Number
Correspondence To Constantine E Kosmas, FACC, FACP, MD, PhD, Attending Doctor, Department of Medicine, Division of Cardiology, Montefiore Medical Center, 111 E 210th St, Bronx, NY10467, United States. cekosmas1@gmail.com
Keywords Lipid-modifying therapies; Cardiovascular disease; Dyslipidemia; ; ;
Core Tip Despite significant progress in the treatment of dyslipidemia, there is still considerable residual risk of recurring cardiovascular events. Ongoing research has led to the discovery of several different molecules involved in lipid homeostasis, which can serve as possible targets for new lipid-modifying therapies. Novel medications that have provided promising results in early human trials include inclisiran, bempedoic acid, seladelpar, CSL-112, apabetalone, volanesorsen, APO(a)-RX, and APO(a)-LRX. Furthermore, several other lipid-lowering agents are being evaluated in ongoing trials. Thus, there is optimism that use of these lipid-lowering medications may in the future lead to a reduction of the residual cardiovascular risk.
Citation Kosmas CE, Sourlas A, Silverio D, Montan PD, Guzman E. Novel lipid-modifying therapies addressing unmet needs in cardiovascular disease. World J Cardiol 2019; In press
Received
2019-03-29 01:51
Peer-Review Started
2019-04-03 08:30
To Make the First Decision
2019-08-06 06:58
Return for Revision
2019-08-20 02:14
Revised
2019-08-22 15:44
Second Decision
2019-09-29 07:06
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-10-07 19:09
Articles in Press
2019-10-07 19:09
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1949-8462 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 00227375, 00608250, 03414056, and 02446694
Editorial Director Ruo-Yu Ma
Journal Chief Editor
Company Chief Editor Na Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 47924-Review.docx
Answering Reviewers 47924-Answering reviewers.pdf
Audio Core Tip 47924-Audio core tip.mp3
Conflict-of-Interest Disclosure Form 47924-Conflict-of-interest statement.pdf
Copyright License Agreement 47924-Copyright license agreement.pdf
Peer-review Report 47924-Peer-review(s).pdf
Scientific Misconduct Check 47924-Scientific misconduct check.pdf
Scientific Editor Work List 47924-Scientific editor work list.pdf