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Publication Name World Journal of Gastroenterology
Manuscript ID 48328
Country of Manuscript Source China
Specialty Gastroenterology and Hepatology
Manuscript type Basic Study
Article Title Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome
Manuscript Source Unsolicited Manuscript
All Author List Chun-Hui Bao, Chun-Ye Wang, Guo-Na Li, Yi-Lu Yan, Di Wang, Xiao-Ming Jin, Lu-Yi Wu, Hui-Rong Liu, Xiao-Mei Wang, Zheng Shi and Huan-Gan Wu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81503656
National Key Basic Research Program of China (973 program) 2015CB554501 and 2009CB522900
Correspondence To Huan-Gan Wu, PhD, Professor, Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, 650 South Wanping Road, Xuhui District, Shanghai 200030, China. wuhuangan@126.com
Keywords Moxibustion; Post-inflammation irritable bowel syndrome; Intestinal microbes; NLRP6 inflammasome; Intestinal inflammation; Visceral hypersensitivity; Traditional Chinese medicine
Core Tip Moxibustion has been shown to have a therapeutic effect on post-infectious/post-inflammatory irritable bowel syndrome (PI-IBS). However, it is unclear whether moxibustion achieves its therapeutic effect by regulating intestinal microbiota and inflammatory responses of PI-IBS. In this study, we found that visceral hypersensitivity and low-grade intestinal inflammation in PI-IBS rats were significantly inhibited by 7 d mild moxibustion treatment. This treatment effect of moxibustion may be related to the regulating the relative abundances of selected gut microbes and controlling NLRP6 inflammasome signaling.
Citation Bao CH, Wang CY, Li GN, Yan YL, Wang D, Jin XM, Wu LY, Liu HR, Wang XM, Shi Z, Wu HG. Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome. World J Gastroenterol 2019; In press
Received
2019-04-15 00:35
Peer-Review Started
2019-04-15 06:44
To Make the First Decision
2019-06-17 00:40
Return for Revision
2019-06-21 02:12
Revised
2019-06-27 04:21
Second Decision
2019-07-05 10:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-07-05 23:43
Articles in Press
2019-07-05 23:43
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-07-15 04:09
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 00503587
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 48328-Review_Edited.docx
Answering Reviewers 48328-Answering reviewers.pdf
Audio Core Tip 48328-Audio core tip.m4a
Biostatistics Review Certificate 48328-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 48328-Conflict-of-interest statement.pdf
Copyright License Agreement 48328-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 48328-Grant application form(s).pdf
Institutional Animal Care and Use Committee Approval Form or Document 48328-Institutional animal care and use committee statement.pdf
Institutional Review Board Approval Form or Document 48328-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 48328-Language certificate.pdf
Peer-review Report 48328-Peer-review(s).pdf
Scientific Misconduct Check 48328-Scientific misconduct check.pdf
Scientific Editor Work List 48328-Scientific editor work list.pdf