Publication Name	World Journal of Gastroenterology
Manuscript ID	48328
Country	China

Category	Gastroenterology & Hepatology
Manuscript Type	Basic Study
Article Title	Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome
Manuscript Source	Unsolicited Manuscript
All Author List	Chun-Hui Bao, Chun-Ye Wang, Guo-Na Li, Yi-Lu Yan, Di Wang, Xiao-Ming Jin, Lu-Yi Wu, Hui-Rong Liu, Xiao-Mei Wang, Zheng Shi and Huan-Gan Wu
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 81503656 National Key Basic Research Program of China (973 program) 2015CB554501 and 2009CB522900
Corresponding Author	Huan-Gan Wu, PhD, Professor, Key Laboratory of Acupuncture and Immunological Effects, Shanghai University of Traditional Chinese Medicine, 650 South Wanping Road, Xuhui District, Shanghai 200030, China. wuhuangan@126.com
Key Words	Moxibustion; Post-inflammation irritable bowel syndrome; Intestinal microbes; NLRP6 inflammasome; Intestinal inflammation; Visceral hypersensitivity
Core Tip	Moxibustion has been shown to have a therapeutic effect on post-infectious/post-inflammatory irritable bowel syndrome (PI-IBS). However, it is unclear whether moxibustion achieves its therapeutic effect by regulating intestinal microbiota and inflammatory responses of PI-IBS. In this study, we found that visceral hypersensitivity and low-grade intestinal inflammation in PI-IBS rats were significantly inhibited by 7 d mild moxibustion treatment. This treatment effect of moxibustion may be related to the regulating the relative abundances of selected gut microbes and controlling NLRP6 inflammasome signaling.
Citation	Bao CH, Wang CY, Li GN, Yan YL, Wang D, Jin XM, Wu LY, Liu HR, Wang XM, Shi Z, Wu HG. Effect of mild moxibustion on intestinal microbiota and NLRP6 inflammasome signaling in rats with post-inflammatory irritable bowel syndrome. World J Gastroenterol 2019; 25(32): 4696-4714

Received	2019-04-15 00:35
Peer-Review Started	2019-04-15 06:44
To Make the First Decision	2019-06-17 00:40
Return for Revision	2019-06-21 02:12
Revised	2019-06-27 04:21
Second Decision	2019-07-05 10:31
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-07-05 23:43
Articles in Press	2019-07-05 23:43
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-07-15 04:09
Typeset the Manuscript	2019-08-28 06:14

ISSN	1007-9327 (print) and 2219-2840 (online)
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