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Publication Name World Journal of Gastroenterology
Manuscript ID 48428
Country of Manuscript Source China
Specialty Oncology
Manuscript Type Basic Study
Article Title Analysis of unfavorable prognostic biomarker of adenoma polyposis coli in period-T4 gastric cancer
Manuscript Source Unsolicited Manuscript
All Author List Weibo Du, Chenhong Lin and Wenbiao Chen
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81571953
Corresponding author Wenbiao Chen, PhD, Doctor, Postdoctoral Fellow, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou , Zhejiang, Hangzhou 310003, Zhejiang, China. chanwenbiao@sina.com
Keywords Adenoma polyposis coli; Gastric cancer; Prognosis; mRNA; miRNA; Methylation
Core Tip We found that high expression of adenoma polyposis coli (APC) was associated with poor prognosis in period-T4 gastric cancer (GC) patients. There was different expression of genes, miRNA and DNA methylation between high expression of APC (APChigh) and low expression of APC (APClow) groups. The APChigh associated with different expression of genes, miRNA and DNA methylation could contributed to the poor prognosis in period-T4 GC patients, and were involved with the pathogenesis of GC. We emphasized the APC, which could be used as novel biomarker to be applied to clinical diagnosis, therapy, and assessment of prognosis in period-T4 GC patients, as well as further research on the pathogenesis of GC.
Citation Du WB, Lin CH, Chen WB. Analysis of unfavorable prognostic biomarker of adenoma polyposis coli in period-T4 gastric cancer. World J Gastroenterol 2019; 25(31): 4452-4467
Received
2019-04-17 23:57
Peer-Review Started
2019-04-18 06:48
To Make the First Decision
2019-06-17 01:17
Return for Revision
2019-06-17 07:21
Revised
2019-07-18 18:04
Second Decision
2019-08-02 10:11
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-07 09:39
Articles in Press
2019-08-07 09:39
Publication Fee Transferred
Edit the Manuscript by Language Editor
2019-08-12 01:06
Typeset the Manuscript
2019-08-19 06:40
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ruo-Yu Ma
Reviewer Code 02523972, and 03001816
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor Tian-Qi Wang
Electronic Editor Yu-Jie Ma
Responsible Electronic Editor Yu-Jie Ma
Responsible Science Editor Ze-Mao Gong
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Full Article (PDF) WJG-25-4452.pdf
Full Article (Word) WJG-25-4452.docx
Manuscript File 48428-Review_Edited.docx
Answering Reviewers 48428-Answering reviewers.pdf
Audio Core Tip 48428-Audio core tip.mp3
Biostatistics Review Certificate 48428-Biostatistics statement .pdf
Conflict-of-Interest Disclosure Form 48428-Conflict-of-interest statement.pdf
Copyright License Agreement 48428-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 48428-Grant application form(s).pdf
Institutional Review Board Approval Form or Document 48428-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 48428-Language certificate.pdf
Supplementary Material 48428-Supplementary material.pdf
Peer-review Report 48428-Peer-review(s).pdf
Scientific Misconduct Check 48428-Bing-MA RY-2.png
Scientific Misconduct Check 48428-Scientific misconduct check.pdf
Scientific Editor Work List 48428-Scientific editor work list.pdf