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Articles in Press
8/7/2019 9:39:37 AM | Browse: 521 | Download: 1122
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Analysis of unfavorable prognostic biomarker of adenoma polyposis coli in period-T4 gastric cancer
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Weibo Du, Chenhong Lin and Wenbiao Chen |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
81571953 |
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| Corresponding Author |
Wenbiao Chen, PhD, Doctor, Postdoctoral Fellow, The First Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou , Zhejiang, Hangzhou 310003, Zhejiang, China. chanwenbiao@sina.com |
| Key Words |
Adenoma polyposis coli; Gastric cancer; Prognosis; mRNA; miRNA; Methylation |
| Core Tip |
We found that high expression of adenoma polyposis coli (APC) was associated with poor prognosis in period-T4 gastric cancer (GC) patients. There was different expression of genes, miRNA and DNA methylation between high expression of APC (APChigh) and low expression of APC (APClow) groups. The APChigh associated with different expression of genes, miRNA and DNA methylation could contributed to the poor prognosis in period-T4 GC patients, and were involved with the pathogenesis of GC. We emphasized the APC, which could be used as novel biomarker to be applied to clinical diagnosis, therapy, and assessment of prognosis in period-T4 GC patients, as well as further research on the pathogenesis of GC. |
| Citation |
Du WB, Lin CH, Chen WB. Analysis of unfavorable prognostic biomarker of adenoma polyposis coli in period-T4 gastric cancer. World J Gastroenterol 2019; 25(31): 4452-4467 |
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Received |
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2019-04-17 23:57 |
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Peer-Review Started |
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2019-04-18 06:48 |
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To Make the First Decision |
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2019-06-17 01:17 |
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Return for Revision |
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2019-06-17 07:21 |
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Revised |
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2019-07-18 18:04 |
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Second Decision |
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2019-08-02 10:11 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Company Editor-in-Chief |
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2019-08-07 09:39 |
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Articles in Press |
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2019-08-07 09:39 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2019-08-12 01:06 |
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Typeset the Manuscript |
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2019-08-19 06:40 |
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