Publication Name	World Journal of Gastroenterology
Manuscript ID	48455
Country	Germany

Category	Gastroenterology & Hepatology
Manuscript Type	Systematic Reviews
Article Title	Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia
Manuscript Source	Invited Manuscript
All Author List	Johanna Waidhauser, Anne Bornemann, Martin Trepel and Bruno Märkl
Funding Agency and Grant Number
Corresponding Author	Bruno Märkl, MD, Professor, Institute of Pathology and Molecular Diagnostics, University Medical Center Augsburg, Stenglinstrasse 2, Augsburg 86156, Germany. bruno.maerkl@outlook.de
Key Words	Gastrointestinal stromal tumor; Associated; Secondary; Neoplasia; Tumor;
Core Tip	Gastrointestinal stromal tumors (GIST) associated neoplasms have been previously reported to occur with a more than coincidental frequency. Numerous case reports, mostly retrospective studies and a few reviews have been published on this topic. In this, to our knowledge, first systematic review we analyzed 108 case reports and 22 retrospective and prospective studies with a total of 12050 patients. An overall rate of GIST-associated neoplasias of 20% could be calculated. Most second neoplasias were found in the gastrointestinal tract (32%) and in the male and female urogenital tract (30%).
Citation	Waidhauser J, Bornemann A, Trepel M, Märkl B. Frequency, localization, and types of gastrointestinal stromal tumor-associated neoplasia. World J Gastroenterol 2019; 25(30): 4261-4277

Received	2019-04-19 01:26
Peer-Review Started	2019-04-19 01:54
To Make the First Decision	2019-06-17 01:16
Return for Revision	2019-06-17 07:14
Revised	2019-06-22 07:09
Second Decision	2019-07-05 10:34
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-07-05 23:41
Articles in Press	2019-07-05 23:41
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-08-14 07:13

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
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