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Publication Name World Journal of Gastroenterology
Manuscript ID 48524
Country/Territory South Korea
Category Gastroenterology & Hepatology
Manuscript Type Retrospective Study
Article Title Value of controlled attenuation parameter in fibrosis prediction in nonalcoholic steatohepatitis
Manuscript Source Unsolicited Manuscript
All Author List Jung Il Lee, Hyun Woong Lee and Kwan Sik Lee
Funding Agency and Grant Number
Funding Agency Grant Number
The National Research Foundation of Korea NRF-2016R1A2B4015192
Corresponding Author Jung Il Lee, MD, PhD, Associate Professor, Department of Internal Medicine, Gangnam Severance Hospital, Yonsei University College of Medicine, 211 Eonju-ro, Gangnam-gu, Seoul 06273, South Korea. mdflorence@yuhs.ac
Key Words Fibroscan; Controlled attenuation parameter; Liver stiffness; Nonalcoholic steatohepatitis; Liver fibrosis;
Core Tip Liver stiffness measurement (LSM) is said to be exaggerated in nonalcoholic fatty liver disease (NAFLD). We investigated the role of controlled attenuation parameter (CAP), a means of measuring steatosis noninvasively, in predicting liver fibrosis by LSM in 184 biopsy proven nonalcoholic steatohepatitis patients. The optimum LSM cutoff for Kleiner fibrosis stage (F) ≥ 2 reflecting CAP values showed higher cutoff with increased CAP tertile (LSM, 8.05 kPa for lower CAP tertile, 9.35 kPa for middle, 10.45 kPa for high CAP tertile). Therefore, we suggest that interpretation of LSM in patients with NAFLD should take CAP scores into account in order to avoid unnecessary liver biopsy.
Citation Lee JI, Lee HW, Lee KS. Value of controlled attenuation parameter in fibrosis prediction in nonalcoholic steatohepatitis. World J Gastroenterol 2019;25(33): 4959-4969
Received
2019-04-24 01:03
Peer-Review Started
2019-04-24 03:57
To Make the First Decision
2019-07-22 03:45
Return for Revision
2019-07-23 03:08
Revised
2019-07-29 09:51
Second Decision
2019-08-02 10:13
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-08-07 09:37
Articles in Press
2019-08-07 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2019-09-04 03:26
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
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