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Publication Name World Journal of Gastrointestinal Oncology
Manuscript ID 48710
Country of Manuscript Source China
Specialty Oncology
Manuscript type Observational Study
Article Title Clinical significance of MLH1/MSH2 for stage II and III sporadic colorectal cancer
Manuscript Source Unsolicited Manuscript
All Author List shui-Ming Wang, Bin Jiang, You-Ping Deng, Shu-Liang Huang, Ming-Zhi Fang and Yu Wang
Funding Agency and Grant Number
Funding Agency Grant Number
Medical Science and technology development Foundation,Nanjing Department of Health, No. YKK14140
Medical Science and technology development Foundation,Nanjing Department of Health, No. ZKX15040
Project of Administration of Traditional Chinese medicine of Jiangsu Province of China, No. LZ11101
Correspondence To Yu Wang, MD, PhD, Chief Doctor, oncology, entern, Nanjing hospital of Chinese medicine, nanjing 210001, China. christinewangyu@outlook.com
Keywords Colorectal cancer; Mismatch repair gene; MLH1; MSH2; Microsatellite instability;
Core Tip Mutation or methylation of mismatch repair gene leads to microsatellite instability (MSI), which is one of the most important mechanisms of colorectal cancer (CRC). The purpose of this study was to collect data of MLH1/MSH2 and MSI status in stage II-III CRC and to assess the predictive and prognostic value of this analysis. This is the first large study in China to evaluate the role of MLH1/MSH2 in CRC and its relationship with adjuvant chemotherapy.
Citation Wang SM, Jiang B, Deng YP, Huang SL, Fang MZ, Wang Y. Clinical significance of MLH1/MSH2 for stage II and III sporadic colorectal cancer. World J Gastrointest Oncol 2019; In press
Received
2019-04-29 01:30
Peer-Review Started
2019-05-09 03:04
To Make the First Decision
2019-08-01 00:23
Return for Revision
2019-08-01 06:48
Revised
2019-08-10 13:43
Second Decision
2019-09-10 10:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-10 23:15
Articles in Press
2019-09-10 23:15
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1948-5204 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Ying Dou
Reviewer Code 00043396, and 02505493
Editorial Director Jin-Lei Wang
Journal Chief Editor
Company Chief Editor Li Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 48710-Review.docx
Answering Reviewers 48710-Answering reviewers.pdf
Audio Core Tip 48710-Audio core tip.mp3
Biostatistics Review Certificate 48710-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 48710-Conflict-of-interest statement.pdf
Copyright License Agreement 48710-Copyright license agreement.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s) 48710-Grant application form(s).pdf
Signed Informed Consent Form(s) or Document(s) 48710-Informed consent statement.pdf
Institutional Review Board Approval Form or Document 48710-Institutional review board statement.pdf
Non-Native Speakers of English Editing Certificate 48710-Language certificate.pdf
Peer-review Report 48710-Peer-review(s).pdf
Scientific Misconduct Check 48710-Scientific misconduct check.pdf
Scientific Editor Work List 48710-Scientific editor work list.pdf