Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	48710
Country	China

Category	Oncology
Manuscript Type	Observational Study
Article Title	Clinical significance of MLH1/MSH2 for stage II and III sporadic colorectal cancer
Manuscript Source	Unsolicited Manuscript
All Author List	Shui-Ming Wang, Bin Jiang, You-Ping Deng, Shu-Liang Huang, Ming-Zhi Fang and Yu Wang
Funding Agency and Grant Number	Funding Agency Grant Number Medical Science and technology development Foundation，Nanjing Department of Health, No. YKK14140 Medical Science and technology development Foundation，Nanjing Department of Health, No. ZKX15040 Project of Administration of Traditional Chinese medicine of Jiangsu Province of China, No. LZ11101
Corresponding Author	Yu Wang, MD, PhD, Chief Doctor, oncology, entern, Nanjing hospital of Chinese medicine, Nanjing 210001, Jiangsu Province, China. christinewangyu@outlook.com
Key Words	Colorectal cancer; Mismatch repair gene; MLH1; MSH2; Microsatellite instability;
Core Tip	Mutation or methylation of mismatch repair gene leads to microsatellite instability (MSI), which is one of the most important mechanisms of colorectal cancer (CRC). The purpose of this study was to collect data of MLH1/MSH2 and MSI status in stage II-III CRC and to assess the predictive and prognostic value of this analysis. This is the first large study in China to evaluate the role of MLH1/MSH2 in CRC and its relationship with adjuvant chemotherapy.
Citation	Wang SM, Jiang B, Deng YP, Huang SL, Fang MZ, Wang Y. Clinical significance of MLH1/MSH2 for stage II and III sporadic colorectal cancer. World J Gastrointest Oncol 2019; 11(11): 1065-1080

Received	2019-04-29 01:30
Peer-Review Started	2019-05-09 03:04
To Make the First Decision	2019-08-01 00:23
Return for Revision	2019-08-01 06:48
Revised	2019-08-10 13:43
Second Decision	2019-09-10 10:19
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-09-10 23:15
Articles in Press	2019-09-10 23:15
Publication Fee Transferred
Edit the Manuscript by Language Editor	2019-09-26 01:34
Typeset the Manuscript	2019-10-23 01:15

ISSN	1948-5204 (online)
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