Publication Name	World Journal of Gastroenterology
Manuscript ID	48774
Country	Ireland

Category	Gastroenterology & Hepatology
Manuscript Type	Minireviews
Article Title	Neoadjuvant radiotherapy for rectal cancer management
Manuscript Source	Invited Manuscript
All Author List	Gerard Feeney, Rishabh Sehgal, Margaret Sheehan, Aisling Hogan, Mark Regan, Myles Joyce and Michael Kerin
Funding Agency and Grant Number	Funding Agency Grant Number NBCRI, Symptomatic Breast Unit, University Hospital Galway
Corresponding Author	Gerard Feeney, MBChB, Doctor, Department of General/Colorectal Surgery, Lambe Institute, Galway University Hospital, Newcastle Road, Galway H91 YR71, Ireland. g.feeney3@nuigalway.ie
Key Words	Rectal cancer; Neoadjuvant therapy; Low anterior resection syndrome; Stoma; Transanal endoscopic microsurgery; Trans-anal total mesorectal excision
Core Tip	Neoadjuvant radiotherapy aims to downstage tumours for a more effective oncological resection. Studies have shown that both long and short course pre-operative radiotherapy confers benefits to local recurrence. Some patients completely respond to radiotherapy and have been enrolled in surveillance programmes without undergoing surgery. It is essential to be aware of the disadvantages associated with radiotherapy. Radiation therapy increases the risk of anorectal and genitourinary dysfunction which have a deleterious impact on quality of life. Thus it is imperative to accurately identify patients who are likely to benefit from neoadjuvant radiotherapy in order to minimise morbidity and improve patient outcomes.
Citation	Feeney G, Sehgal R, Sheehan M, Hogan A, Regan M, Joyce M, Kerin M. Neoadjuvant radiotherapy for rectal cancer management. World J Gastroenterol 2019;25(33): 4850-4869

Received	2019-05-09 02:27
Peer-Review Started	2019-05-10 03:17
To Make the First Decision	2019-07-22 02:18
Return for Revision	2019-07-22 06:26
Revised	2019-07-28 21:52
Second Decision	2019-08-02 10:14
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2019-08-07 09:37
Articles in Press	2019-08-07 09:37
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2019-09-04 03:23

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access	This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright	© The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com