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Publication Name World Journal of Gastroenterology
Manuscript ID 48807
Country of Manuscript Source United Kingdom
Specialty Gastroenterology and Hepatology
Manuscript type Retrospective Study
Article Title Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres
Manuscript Source Unsolicited Manuscript
All Author List Melissa Frizziero, Xin Wang, Bipasha Chakrabarty, Alexa Childs, Tu Vinh Luong, Thomas Walter, Mohid S. Khan, Meleri Morgan, Adam Christian, Mona Elshafie, Tahir Shah, Annamaria Minicozzi, Wasat Mansoor, Tim Meyer, Angela Lamarca, Richard A Hubner, Juan W Valle and Mairéad G McNamara
Funding Agency and Grant Number
Correspondence To Mairéad G McNamara, BM BCh, MD, MSc, PhD, Attending Doctor, Doctor, Senior Lecturer, Senior Researcher, Department of Medical Oncology;Key Laboratory of Malignant Tumor Gene Regulation and Target Therapy of Guangdong higher Education Institutes, The Christie NHS Foundation Trust, 550 Wilmslow Road, Manchester M20 4BX, United Kingdom. mairead.mcnamara@christie.nhs.uk
Keywords Mixed neuroendocrine non-neuroendocrine neoplasm; 2017 World Health Organisation classification; Mixed adeno-neuroendocrine carcinoma; Gastro-entero-pancreatic tract; Digestive system; Neuroendocrine neoplasms
Core Tip Mixed neuroendocrine non-neuroendocrine neoplasm (MiNEN) is a rare, albeit aggressive diagnosis. Evidence from literature is limited and inconsistent. This study reports on one of the largest cohorts of patients with a diagnosis of MiNEN in the current literature, and aims to provide useful suggestions for clinical management, in the absence of data from clinical trials. Potentially curable cases are most commonly offered surgery alone or in combination with chemotherapy or chemo-radiotherapy (predominantly according to the ‘standard of care’ for adenocarcinomas). Advanced cases are most often treated with palliative chemotherapy and protocols follow either the ‘standard of care’ for adenocarcinomas or neuroendocrine carcinomas.
Citation Frizziero M, Wang X, Chakrabarty B, Childs A, Luong TV, Walter T, Khan MS, Morgan M, Christian A, Elshafie M, Shah T, Minicozzi A, Mansoor W, Meyer T, Lamarca A, Hubner RA, Valle JW, McNamara MG. Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres. World J Gastroenterol 2019; In press
Received
2019-05-02 05:55
Peer-Review Started
2019-05-04 10:13
To Make the First Decision
2019-05-31 00:45
Return for Revision
2019-06-06 02:25
Revised
2019-08-15 06:27
Second Decision
2019-09-10 10:39
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2019-09-10 21:07
Articles in Press
2019-09-10 21:07
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2019. Published by Baishideng Publishing Group Inc. All rights reserved.
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Assistant Editor Xiang Li
Science Editor Jia-Ping Yan
Reviewer Code 03548113, 00050849, and 02445679
Editorial Director Ze-Mao Gong
Journal Chief Editor
Company Chief Editor Lian-Sheng Ma
Language Editor
Electronic Editor
Responsible Electronic Editor
Responsible Science Editor
Proofing Editorial Director Jin-Lei Wang
Proofing Editor-in-Chief Lian-Sheng Ma
Manuscript File 48807-Review.docx
Answering Reviewers 48807-Answering reviewers.pdf
Audio Core Tip 48807-Audio core tip.m4a
Biostatistics Review Certificate 48807-Biostatistics statement.pdf
Conflict-of-Interest Disclosure Form 48807-Conflict-of-interest statement.pdf
Copyright License Agreement 48807-Copyright license agreement.pdf
Institutional Review Board Approval Form or Document 48807-Institutional review board statement.pdf
Supplementary Material 48807-Supplementary material.pdf
Peer-review Report 48807-Peer-review(s).pdf
Scientific Misconduct Check 48807-Scientific misconduct check.pdf
Scientific Editor Work List 48807-Scientific editor work list.pdf